This EMBO Workshop will focus on the molecular mechanisms of telomere biology and how this is compromised in human genetic disorders, ageing and cancer. This reflects exciting recent developments in the field linking shelterin and telomerase pathway mutations to a range of human diseases.
Thanks to next-generation sequencing, we have started to unravel the cancer genomic landscape of several major cancer entities that contributes to the pathogenesis and/or evolution of the disease. For the majority of cancer subtypes, a quite diverse and complex mutation pattern is observed, with a limited number of frequently mutated genes accompanied by a long tail of genes with low-frequency mutations. Some of these genes have already been implied to have diagnostic, prognostic/predictive and even therapeutic impact, while most mutations still require functional validation. In parallel, large efforts have been made to design novel strategies targeting key cellular pathways and processes, which in turn has led to introduction of targeted therapy in selected entities. However, there is still a gap-of-knowledge and urgent medical need how to combine the genetic information with risk-stratification and treatment algorithms in the individual patient, i.e., precision medicine. This symposium will exemplify large sequencing efforts carried out in different cancer types, including both solid tumors and hematological malignancies, which paved the way for the incorporation of next-generation sequencing-based approaches into clinical routine diagnostics and every-day patient care. The conference will encompass the rapidly evolving field of disease monitoring by ultra-sensitive sequencing of tumor-specific mutations, as well as introduce novel approaches and other omics technologies and functional studies that will aid future efforts in precision medicine. Finally, successful examples of how genomic findings have spurred development of targeted therapies will be presented. In summary, the symposium will bring together basic scientists, translational researchers and clinicians to meet and discuss a consorted action towards precision medicine in cancer.
- DNA replication stress
- DNA replication biology
- High-throughput technologies
- Disease development
- ecombination mechanism
- Links between replication and recombination
- Maintenance of genome stability
- Chromosome interactions and meiosis
Genome instability is a hallmark of cancer cells but also a cause of genetic diseases in humans. Our understanding of the causal relationships between genome instability and the development of human diseases rely on our knowledge of the fundamental mechanisms of DNA metabolism, including spatial genome organization to genome expression and regulation during development or in response to environmental stress.
The dysfunctions of basic mechanisms linked to genome metabolism underlie human diseases including cancer.
Maintenance of genome integrity lies at the heart of cell homeostasis. While DNA repair mechanisms have received significant attention for more than half a century, the contribution of the chromatin environment and nuclear organization to genome maintenance has only begun to emerge over the past decade. It is evident that chromatin, being the actual substrate for repair machineries, is heavily remodeled following damage detection and exerts a key function in both targeting and regulating repair at different genomic loci.
This EMBO Workshop brings together an outstanding group of scientists from around the world, young researchers as well as leaders in the field, to cover the following, emerging topics in chromatin, nuclear organization and genome maintenance (i) DNA repair in distinct nuclear domains, (ii) chromatin motion in response to DNA damage, (iii) histone modifications and nucleosome dynamics following DNA damage and (iv) regulatory functions of transcription and RNA during DNA repair and replication stress.
The 2018 Gordon Research Conference on Mutagenesis will focus on the causes and consequences of mutagenesis, addressing topics ranging from the fundamental molecular mechanisms of mutagenesis through the roles of mutagenesis in biology and disease to the exploitation of mutagenesis and mutagenic mechanisms for therapy.
This FASEB SRC will unite scientists pushing the boundaries of our molecular understanding of the nucleic acid transactions which facilitate life. Information encoded in RNA and DNA is accessed, maintained, decoded and degraded by a staggering number of proteins, protein/DNA and protein/RNA complexes that catalyze specific fundamental enzymatic reactions which drive nucleic acid transactions— not limited to, but including key cellular processes such as DNA replication and repair, recombination, transposition, transcription, translation and epigenetic gene regulation. These protein and RNA machines are impacted in varying disease states, and can be exploited for therapeutic advantage including using CRIPSR gene editing technologies. The use of emerging biophysical methodologies such as single-molecule spectroscopy/microscopy and small-angle X-ray scattering, cryo electron microscopy, and chemical biology has opened new doors to exploration of nucleic acid metabolism. This meeting will highlight exciting efforts underway to decipher the anatomy, architecture and mechanisms of these protein and protein-nucleic acid machines in order to understand how they recognize, engage, and manipulate the structure of DNA and RNA...
Our new 'Medicine at the Crick' event, "Gene and gene-editing therapy: A new challenge and opportunity in Clinical Medicine" aims to showcase major advances in biomedical science and raise awareness of the medical implications of major scientific advances amongst the Crick and wider UK biomedical community.
The format is a series of short talks, followed by a keynote lecture and a panel discussion. We chose the theme of gene therapy and gene editing to launch the series. The event will be led by Professor Robin Lovell-Badge from the Crick and the keynote lecture will be given by Professor Matthew Porteus from Stanford University. Other speakers and panellists include Dr Claire Booth (UCL Great Ormond Street Institute of Child Health), Professor Sarah Tabrizi (UCL Institute of Neurology), Dr Sarah Chan (University of Edinburgh) and Nick Meade (Genetic Alliance UK).
The theme of the Congress is ‘From Fundamental Insight to Rational Cancer Treatment’, covering the journey of discovery and development ‘from bench to bedside’. The Congress will feature world-class speakers discussing the most innovative current research topics, including a special education track aimed at clinicians. As well as high-profile plenary sessions, the programme offers parallel symposia, allowing participants to build their own scientific programme according to their interests.
The 2018 Genome Instability GRC aims to bring together an outstanding and diverse group of established and younger researchers from North America, Europe and Asia to share their latest research findings on chromosome replication, genome maintenance, and chromatin dynamics.
The Chromatin Structure and Function GRC is one of the longest standing conferences on chromatin, dating back to the 1970s. The meeting covers timely and important topics, including: X-ray crystallization and biophysical studies of individual nucleosomes and higher order structures, the identification and functions of histone post-translational modifications, the regulation and structure of histone modifying enzymes, the components and mechanisms of action of ATP-dependent chromatin remodeling assemblies, replication-dependent and replication-independent mechanisms of chromatin assembly, nucleosome positioning and phasing, the functions of histone variants, gene silencing in heterochromatin, chromatin remodeling during gene activation and repression in euchromatin, chromatin remodeling during DNA repair and recombination, the importance of heterochromatin organization at centromeres and telomeres to the maintenance of genome integrity. The role of chromatin remodeling factors and histone modifications to large scale organization of chromosomes and the location of loci within the nucleus are also discussed, as is the role of chromatin modifications and DNA methylation in epigenetics, particularly with regards as to how mutations in chromatin remodeling and histone modifying activities affect developmental processes and contribute to human disease.
The helical nature of the double helix causes a topological problem for its replication. Watson and Crick were well aware of this potential problem, and in 1953 they stated: "Since the two chains in our model are intertwined, it is essential for them to untwist if they are to separate... Although it is difficult at the moment to see how these processes occur without everything getting tangled, we do not feel that this objection will be insuperable." We now know that this problem is solved by the DNA topoisomerases, which were first reported in 1971 by James Wang, with the discovery of bacterial topoisomerase I. Over the past ~40 years these enzymes have been found in all organisms (prokaryotes, eukaryotes, viruses and archaea) and to perform roles that are vital for survival, supporting replication, transcription and other processes where topological problems in DNA need to be resolved. The enzymes are ‘marvelous molecular machines’ catalyzing the seemingly magical task of passing one piece of DNA through another to catalyze changes in DNA topology. Some of the enzymes are molecular motors having the ability to transduce the free energy of ATP hydrolysis into torsional stress in DNA (supercoiling). Although the outline of their mechanisms has been established, a great deal is unknown and emerging technologies, such as single-molecule methods, need to be applied to gain a deeper understanding of these enzymes and their roles in cellular processes. Topoisomerases have also become key drug targets both for anti-bacterial and anti-cancer chemotherapy. This is due to their essential nature and because of their mechanism of action, which involves transient DNA cleavage that, if disrupted, can lead to highly cytotoxic events. Study of these enzymes in the context of myriad cellular processes is of key importance in research leading to the development of new chemotherapeutic agents.
- Chromosome dynamics
- Nuclear architecture
- DNA transcription, replication and segregation
- Hi-C and polymer modelling
- Molecular mechanisms
- Structural and functional imaging approaches
- Genome integrity
This interdisciplinary symposium will highlight exciting new insights into the molecular principles that govern the functional framework of genomes in space and time. The meeting program will cover all levels of organisational complexity, from DNA to chromosomes, and in model systems ranging from bacteria to humans. A particular highlight will be the integration of discoveries made in different disciplines, including cell and molecular biology, biophysics, modelling, structural biology and biochemistry.
This symposium aims to bring together scientists from different disciplines working at the forefront of chromosome biology to discuss the most recent advances in the field. By combining efforts from biology, physics and chemistry, the programme will open new horizons for future research in this exciting area of the life sciences.
Aging is the single biggest risk factor for the development of organ dysfunction and diseases. Even though under debate, there is a strong association between stem division rates and declines in stem cell function possibly impinging on the selection of mutant stem cells in aging, impairments in tissue maintenance and disease development. There are several new therapeutic targets and basic concepts on the causes and consequences of stem cell and organism aging that will be discussed at this meeting.
Principal themes and objectives of the meeting
A unifying theme of this meeting will be the interaction of researchers that study basic principles of stem cell and tissue maintenance in aging. The meeting will focus on basic molecular and genetic processes that affect genetic and epigenetic stability, protein homeostasis, and metabolic processes thereby impairing the functionality and self renewal of stem cells, and organ maintenance.
The meeting will focus on basic mechanisms as well as innovative animal models and humanized models of aging. In addition, there will be fields such as stem cell niches and circulatory factors, developmental biology, cell plasticity, and clonal dominance. These processes all have tremendous impact on our understanding of organism aging.
Following on from the ISREC Symposia in 2011 to 2016, the next ISREC Symposium, to be held in Lausanne in September 2018, will focus on broad themes – horizons – in cancer biology and therapy.
Bringing together scientists working with eukaryotes, bacteria and archaea, and employing interdisciplinary methodological approaches, this EMBO Workhshop aims to decipher the common pathways which ensure genome maintenance during the cell division cycle of all organisms and how they may affect cell fate choices.
Topics will include:
- Replication origins
- Replisome structure and function
- Replication-transcription collisions and arrested forks
- Replication timing
- DNA and chromosome dynamics
- 3D nuclear organization, chromatin structure and epigenetic regulation
- Chromosome condensation and cohesion
- Chromosome segregation mechanisms and regulation
- Coordination of replication and segregation
- Links with cell fate choices
We aim to bring together, in an informal atmosphere, an outstanding and diverse group of scientists working at the forefront of this field. The meeting sessions will cover all relevant aspects of DNA polymerases, including their structure and biochemistry, their genetics, their roles in mutagenesis, fitness and pathologies as well as their applications to molecular biology and medicine. With the goal of stimulating cross-fertilization we are also inviting a number of speakers from fields related to the DNA polymerase field.
Genomes of living organisms are exposed to damage arising from different sources. To maintain genome integrity, cells and organisms have evolved elaborate mechanisms and signaling pathways that regulate different processes including DNA repair and cell cycle. Recent findings highlighted the intricate interplay between genome stability maintenance and RNA metabolism: Transcription can interfere with DNA replication and thus pose a serious threat to genome stability. Conversely, DNA damage activates signaling pathways that globally affect transcription, splicing and RNA stability. Moreover, non-coding RNA and RNA-binding proteins play an integral part in DNA repair and DNA damage response. This EMBO Workshop will gather established scientists and junior researchers that study the mutual interactions between the DNA damage response and RNA metabolism. The workshop will provide a forum for open and inspiring discussions between the scientists that shaped and the ones that recently joined this exciting and rapidly progressing field on the following topics:
- Replication-transcription conflicts and transcription-associated DNA damage
- RNA-binding proteins in genome stability maintenance
- Non-coding RNA in the DNA damage response
- Interplay between the DNA damage response and RNA metabolism
The NCRI Cancer Conference is the UK’s largest forum showcasing the latest advances in cancer research. The Conference provides a platform for researchers, clinicians, people affected by cancer and industry representatives to come together to discuss, present and showcase high-quality research. Informative and interactive educational sessions attract over 1,500 delegates each year and create the ideal setting to establish new collaborations with key stakeholders in cancer research.
More details to follow:
As postdocs we are under increasing pressure to succeed, and facing the challenge to move on to tenured employment can lead us down many diverse paths. In order to have a competitive advantage we need to build networks with other researchers within and increasingly outwith our chosen field of research.
The Journey from Genes to Disease is a free one day symposium, held in central Oxford and organised by the Postdoctoral Training Fellows at MRC Harwell Institute. The theme is the influence of genetics and genetic regulation in modelling human disease – from molecular through cellular to whole animal level and encompassing developmental, environmental and behavioural interactions.
This meeting will bring together researchers from disparate areas with a common interest in PARPs and poly(ADP-ribosyl)ation. Sessions will include:
- Mono(ADP-ribosyl) Transferases and Cellular Signaling
- DNA Repair, Genome Instability, Cancer, and Aging
- PARPs in the Nucleus and Signaling
- Chemical Biology and Proteomics
- Structure and Mechanisms
- NAD+ metabolism, Inhibitors, and Analogs
The 2018 Gordon Research Conference on DNA Damage, Mutation and Cancer is developed around the theme of exploiting fundamental knowledge to advance treatment and prevention. Rich and ever-increasing information is available on the specific mutations that are the molecular basis of cancer. Many mutations can be traced to specific types of damage to the DNA, while others arise from DNA replication errors or unknown causes. Technologies are being refined to determine the origins of these mutations, and monitor the accuracy and reproducibility of cancer genomic data. Biological and structural analyses can assess which mutations are functionally relevant. Specific mutations can confer vulnerabilities, making individual cancers more responsive to treatment with DNA damaging agents.
Understanding the principles governing genome regulation is one of the major challenges now facing biomedical research in the 21st century. Deciphering structure-activity relationships of the genome and its partners in the context of the cell nucleus is a necessary step for understanding the basis of development and disease, as well as for the elaboration of strategies against particular forms of cancers and genetic disorders. The genome is not a linear molecule of DNA randomly distributed in the nucleus, but exists as a three-dimensional (3D) object, intricately folded and packaged, structured around nuclear bodies and landmarks, acted upon by countless force-generating nano-machines and remodeling factors. With the recent advances that have been made in microscopy, biochemistry and modeling, the time is ripe to fully address the study of the genome in 3D space and time and consider it as a complex, dynamic biological system. Up until recently, many of the scientists involved in chromatin biology and epigenetics would attend meetings dedicated to this topic and would not necessarily interface with scientists using advanced imaging or physical and mathematical modeling approaches. This meeting will bring together some of the world’s leading experts and emerging talents at the interface of these topics to explore chromosome architecture and its dynamic relationship with genome function. Specifically, it will explore: 1) Chromatin structure and how this relates to gene expression and genome functions such as DNA replication and repair; 2) Chromosome conformation and the new insights into genome organization that have emerged using new technologies; 3) The nature of the chromatin partners (proteins, RNAs) that underlie chromatin folding and functions and their dynamic relationships in different contexts (cell cycle, development, environmentally induced changes, etc.); 4) Emerging imaging technologies and microscopy and the answers they are bringing to the dynamics of chromatin and chromosome architecture; and 5) New physical and mathematical modeling approaches to further our understanding of the principles governing chromatin architecture.
This is the second EACR conference focused on this topic. It is designed to be of interest to cancer scientists and medical oncologists with expertise in basic, translational and clinical research. Its objective is to cover recent and exciting developments in the field that are crucial to our understanding of the multifaceted role of the DNA damage response and associated tumour cell specific alterations in cancer initiation, progression and precision cancer therapy.
The London Cell Cycle Club provides a venue for labs doing fundamental cell cycle research in model organisms to interact with those using mammalian cells to drive research in a more ‘translational’ direction.
In addition, the meeting provides a forum of expertise in cell cycle biology to critique new work, enabling new ideas to be ‘distilled’ prior to publication.
- Encourage discussion in a relaxed atmosphere
- Provide an opportunity for students and post-docs to present new and unpublished data
- Inspire new collaborations within the UK and European cell cycle field
With the rapidly emerging new tools including genomics, bioinformatics, metabolomics and proteomic analysis and new powerful editing tools such as CRISPR/CAS9 we are getting closer to more defined understanding of the complex cellular pathways underpinning neurodegeneration, which underlie many debilitating pathological and age-associated neurological demise. This is a great opportunity to assemble a rich programme of international speakers to address the latest advances from basic research to clinical applications in disorders of the central nervous system.
The conference will primarily focus on amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD), spinal muscular atrophy (SMA), Alzheimer’s disease/dementia, and repeat expansion disorders with translational spin focussing on recent advances in gene based-therapeutics.
CRUK Cambridge Institute Annual International Symposium 'Unanswered Questions in Precision Medicine’, Cambridge, UK
The symposium will include sessions on:
- Target and biomarker validation
- Clinical and pre-clinical
- Developing target strategies
- What makes a good target?
The remarkable stability of the human genome is lost in cancer cells due to the loss of efficient and accurate repair in the context of oncogene-induced replication stress and elevated transcription. DNA replication is furthermore emerging as a surprisingly fragile and complex process requiring fork protection and restart, R-loop resolution, and repair. Unresolved replication and repair intermediates signal apoptosis. The synthetic lethality and essentiality resulting from replication-repair stresses thus suggest repair inhibitors as tools to control pathway selection and damage outcomes and to design advanced therapeutics. The 2018 DNA Replication and Repair Structures & Cancer conference will focus on structural and mechanistic insights into dynamic protein, DNA and RNA complexes acting in DNA replication and repair events relevant to cancer.
This symposium is a large and important event that gather scientists and clinicians and aims at presenting an overview of new concepts and studies in the field of oncology.
The program for 2018 will include 6 sessions (Metastasis and microenvironment, Genetic instability and DNA damage, Epigenetics and Non coding genome, Cancer immunotherapy, New therapeutic strategies and Clinical Research).
4th EACR Conference: A Matter of Life or Death: From Basic Cell Death Mechanisms to Novel Cancer Treatments, Amsterdam, The Netherlands
Evading cell death is a hallmark of cancer cells, which contributes to tumour growth and therapeutic resistance. But cancer cells also highjack mechanisms like protective autophagy or senescence to promote tumour growth. Cell death is an important determinant of the immune response to cancer, which may either increase the antitumour effect or promote tumour growth. The conference will cover exciting new insights into this highly-relevant field
Scientific Organizers: David Komander and Sylvie Urbé
These are exciting times for ubiquitin research: potential targets for small molecule inhibitors are emerging in a variety of human diseases and being exploited by the pharmaceutical industry. At the same time new enzymes regulating ubiquitin modifications are still being discovered, and the complexity of ubiquitin modifications continues to increase with the emerging cross-talk between post-translational modifications. This meeting will focus on the latest insights in the large area of cellular regulation mediated by ubiquitin and ubiquitin-like modifiers. Key goals are to provide overviews and updates on emerging frontiers, inform on new developments to understand the complexity, and encourage efforts to exploit the system to provide new treatments for human diseases. Rather than being organized around key enzymes in the cascade, sessions will focus on biological areas, ensuring a balanced mix of mechanistic and physiology aspects. The meeting will feature both key opinion-leaders on ubiquitination who are known to present unpublished results and leading researchers from peripheral fields who will contribute new ideas. A short selection of company-associated academic speakers will provide insights into the translational opportunities in this area.
Current Trends in Biomedicine 2017 workshop on "Chromosomal Instability: From Molecular Mechanisms to Disease"
Pablo Huertas (Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Sevilla, Spain)
Andres J. López-Contreras (Center for Chromosome Stability (CCS), University of Copenhagen, Copenhagen, Denmark)
Guillermo de Cárcer (Spanish National Cancer Centre (CNIO), Madrid, Spain)
Come and participate in this free half day meeting, present your research and hear about the latest developments in the field of chromatin biology.
The London Chromatin Meeting is a series of meetings which provide a forum for scientists (especially students and young postdocs) to present their work and for attendees to network in a relaxed and friendly environmen.
The maintenance of genome stability takes place in a chromatin environment, and it is increasingly evident that epigenetic regulation is a key component of genome stability. Notably, epigenetic pathways are frequently perturbed in cancer cells. Understanding the interplay between epigenetic regulation and genome stability at a molecular level is critical to cancer biology and has important translational implications.
The programme will address the challenges of understanding this complex field and will emphasise new experimental systems for interrogating these pathways. While the emphasis is on understanding molecular mechanisms of epigenetic impacts on genome stability, we will also consider how recent advances can be exploited in the clinic.
This year’s Summit revolves around “Re-imagining the Patient Journey”, seeking to create a forum that brings together all rare disease stakeholders in a spirit of collaboration, innovation and passion to re-imagine and re-invent the rare disease patient journey.
We have listened closely to the excellent feedback from delegates in 2016 to bring more powerful patient stories, tracing the journey from early symptoms through their odyssey to diagnosis and their successful patient group, clinician and pharma collaborations leading to clinical trials and hope for future treatment pathways.
Anchored by powerful patient voices, this one-day conference will explore:
- Rare disease patient journeys from symptoms through to treatment
- Empowering the patient revolution
- Data mining and management
- Pharma 'adopting' a rare disease
- Drug re-purposing and matching
- Gene therapy
- Local rare disease research and projects
The discovery of the RNA programmable nucleases Cas9 and Cpf1 has greatly facilitated genome editing. The impact of CRISPR technology has been universal, bringing drug discovery to an era of whole genome knockout screens and widely distributed multiplexed in vivo gene editing experiments, as well as moving into the clinic to join ZFN and TALEN powered therapies progressing towards registration.
This unique meeting, being held in Dublin, will bring leaders in the field of gene editing together with a wide academic and commercial audience, to explore the new horizons in drug development and therapeutics brought by advancements in CRISPR technology.
DNA Repair Mechanisms & Consequences
A Tribute to Philip C. Hanawalt
Opening Keynote: Aziz Sancar, Nobel Laureate
Keynote Talks: Wim Vermeulen, Jan Hoeijmakers
Organizers: Priscilla Cooper, Mats Ljungman, Leona Samson, Susan Wallace, Robert W. Sobol
We have succeeded to gather world-leading scientists working in the diverse research areas that are relevant for understanding the biology of ageing. The meeting will begin on October 8th with an Opening Lecture by Professor Andrew Dillon, Thomas and Stacey Siebel Distinguished Chair in Stem Cell Research at the Department of Molecular and Cell Biology at Berkeley.
The programme of the Meeting is organized into 10 sessions covering a wide range of topics related with the process of ageing.
This EMBO Conference will cover chromosome structure and organization, epigenetic modifications, chromatin remodelling and reprogramming, silent chromatin, genome stability and telomere biology, replication and repair, nuclear RNA, systems biology of genome functions and nuclear compartments.
The DNA damage response (DDR) is a complex signaling network including cell cycle checkpoints, DNA repair and DNA-damage tolerance pathways. The DDR is affected by, and impacts on, many cellular components and processes, including chromatin structure, DNA replication, transcription and cell cycle progression. Failure to properly respond to DNA damage leads to genomic instability, an underlining cause of various human syndromes and also associated with many age-related diseases, particularly cancer. Notably, it is becoming clear that the DDR is an attractive therapeutic target for cancer and other disease areas. This EMBO Conference will cover all the above topics in ways that will link detailed molecular mechanisms of the DDR and associated processes to human ageing, disease and therapeutic applications.
The 2nd International Ataxia Research Conference will be held on September 27-30, 2017 in Pisa, Italy. The focus of the meeting is a comprehensive scientific review of new research from disease definition to therapeutic treatments. The conference will include Friedreich’s ataxia and other recessive ataxias (eg: ataxia with oculomotor apraxia), dominant ataxias (eg: spinocerebellar ataxias, DRPLA, episodic ataxias) and autoimmune ataxias.
The scientific theme for this meeting like most Biotexcel meetings will cover the areas where Next Generation Sequencing is used in the analysis of human disease. These topics will include different disease areas where particularly promising genomic studies have been performed; large population studies such as the East London Genes & health project; whole genome & whole exome studies; epigenomics and many other topics. In this meeting we will also hear from commercial genomic companies, whether those that currently have genomic solutions on the market, or those that are spin-outs or in the research or earlier phases, as well as hearing from Illumina’s Chief Scientist David Bentley.
Details to follow...
The meeting aims to gather scientists and clinicians interested in cancer biology and its therapeutic innovations, and to present the latest scientific advances in these fields.
Through the participation of internationally renowned scientists, the Symposium aims to address crucial questions about the fundamental issues of cancer biology with a special emphasis on interactions between basic, clinical and translational research.