This year’s meeting will be hosted by Professor Richard Gilbertson and will focus on the aims and achievements of the CRUK Cambridge Centre.
Further details will follow
This year’s meeting will be hosted by Professor Richard Gilbertson and will focus on the aims and achievements of the CRUK Cambridge Centre.
Further details will follow
2019 is coincidentally the centenary of both the Genetics Society and the origins of the Roslin Institute and the Institute of Evolutionary Biology, University of Edinburgh. A joint scientific celebratory meeting will be held from 13-15th November 2019, Edinburgh.
Excellent scientific, public outreach and social programmes are being formulated.
The scientific meeting will focus on the work of prominent scientists who have connections with Edinburgh.
Evading programmed cell death is a major hallmark of cancer cells and contributes to tumour progression and therapy resistance. Emerging hallmarks such as metabolic plasticity, genomic instability and an immunosuppressive tumour environment allow the tumours to escape from standard cytotoxic as well as targeted therapies. Thus, understanding the underlying mechanisms in appropriate pre-clinical/clinical models is crucial for the design of more effective combination therapies to avoid treatment failure or tumour recurrence.
Building on the strong success of four previous editions, this will be the 5th conference on this topic. Its objective is to cover recent and exciting developments in the field of cancer research that are crucial to our understanding of the multifaceted role of cell death in tumour initiation, progression and therapy response.
This conference will focus on structural and mechanistic insights into dynamic protein, chromatin, DNA and RNA complexes acting in DNA repair and its interface with DNA replication and transcription events relevant to cancer. This fundamental information will be pivotal for the accurate interpretation of cancer clinical data, design of clinical trials, prognosis, etiology and improving the currently 1/20 low success rate for oncology drug clinical trials. Informative talks and poster sessions along with vibrant discussions will foster productive interactions and collaborations.
This GRC will be held in conjunction with the "DNA Damage, Mutation and Cancer (GRS)" Gordon Research Seminar (GRS). Details tba
The conference will address state-of-the-art basic and translational cancer research, focusing on recent discoveries in immunotherapy, genetic alterations, metabolism, microbiome, tumor microenvironment, senescence, cancer progression and metastases, and innovative technologies in cancer therapy. The program will include presentations by leading scientists and clinicians, and short talks selected from abstracts.
Mammalian genomes are folded in a hierarchy of compartments, topologically associating domains (TADs), subTADs, and looping interactions. As genome-wide chromatin architecture maps become widely available, the field is shifting focus from mapping to understanding the dynamics of such structures in development, the cell cycle, and on short time scales in single cells. A critical emerging goal will be to unravel the cause and effect relationship between genome folding and functions such as transcription, replication, recombination, and stability/maintenance. There is also a great need to evaluate the organizing principles governing chromatin topology across many biological conditions and genetic perturbations. Moreover, the role for 3D genome misfolding in the onset and progression of a wide range of human disease states remains an area of high interest across multiple disciplines and organ systems. The conference program will also include workshops on: (1) Leading computational methods to identify biologically relevant patterns in Hi-C data, (2) New genome mapping and imaging technologies, and (3) New data resources available through the 4D Nucleome consortium. Finally, we will conclude with a session devoted to novel tools for imaging and engineering the 3D genome. Overall, the 2020 Keystone meeting is meant to highlight new frontiers across disciplines in tackling the dynamics and functional roles of the 3D genome in cellular functions across time and space in development and disease.
In this conference, we aim to bring together researchers working on understanding DNA damage responses in the context of complex and dynamic cellular environments. This is an exciting and fast moving area, and this conference features an excellent international line-up of speakers. The programme will address the challenges of understanding this complex field and will emphasise new experimental approaches for interrogating these pathways. We will also consider how recent advances can be exploited in the clinic.
Knowing how cells respond to DNA damage is critical to our understanding of tumourigenesis, genomic instability, and the cellular response to DNA-damaging chemotherapy and radiotherapy. DNA damage responses take place in the context of chromatin and in the midst of ongoing transcription and replication. Moreover, the metabolic environment, which is altered in tumour cells, influences these activities.
This conference will be relevant to participants from different fields of cancer research, including radiation biology, DNA damage responses, DNA repair, epigenetics, and cancer biology. We have created a programme that brings together basic scientists with translational and clinical researchers. Given its translational character, the conference is also of interest for pharma companies. During the meeting, there will be great opportunities for young scientists to present their work and meet the experts in the field, and we aim to create an open and engaging environment for networking and discussion.
DNA damage responses
Epigenetic and metabolic impacts on DNA repair
Interplay between transcription and DNA repair
Immune responses in the context of DNA damage
Implications for radiotherapy
The AACR Annual Meeting program covers the latest discoveries across the spectrum of cancer research—from population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy—and highlights the work of the best minds in research and medicine from institutions all over the world.
This GRC will be held in conjunction with the "Genomic Instability (GRS)" Gordon Research Seminar (GRS). Details tba
This conference, entitled "Genome Stability and DNA Repair" seeks to connect emerging mechanisms of DNA repair and replication with genome stability. The significance and complexity of the DNA damage response cannot be understated, with a central role in reproduction, development, and genome evolution, as highlighed by the many human disease states that occur from genome instability stemming from DNA repair deficiency. The scientific program reflects the importance of classical processes such as DNA replication and homology directed DNA repair in genome integrity, while highlighting emerging aspects of the DNA damage response involving noncoding RNA, chromatin recognition and organization, and catastrophic rearrangements that emanate from mitosis. An additional area of innovation is the realization that genome stability influences human physiology through its signaling to metabolism, the immune system, hematopoietic stem cells, and developmental biology. We will emphasize the importance of fundamental DNA repair mechanisms to organismal biology in normal and pathophysilogic states, including opportunities to exploit the DNA damage response for therapeutic gain and genome engineering. The scientific program encompasses two keynote speakers, eight plenary sessions and four workshops, that collectively, represent the most exciting aspects of the field and bring together a scientifically diverse group of international investigators to promulgate interdisciplinary areas of exploration.
This conference is a continuation of the DNA Replication as a Source of DNA Damage series.
The maintenance of genome integrity is critical for the suppression of several pathological disorders in humans, including cancer, infertility and neurodegeneration. Moreover, the accumulation of unrepaired errors in DNA is commonly cited as a likely cause of tissue and organismal ageing. Destabilization of the genome can occur as a result of several cell intrinsic or extrinsic factors, including errors arising during DNA replication or chromosome segregation, as well as exposure of cells to agents that induce DNA damage. In this conference, we aim to bring together scientists studying DNA replication, DNA repair and chromosome segregation with those interested in how chromosomal instability can influence human pathology. Moreover, we aim to show how high throughput and high content screening methods can be used as a discovery tool both for basic science applications and to identify potential therapeutic modalities.
Pathways for repair of DNA damage and disrupted DNA replication forks
Screening tools for analysis of genome maintenance pathways and for development of new therapeutics
Chromosome fragility caused by difficult-to-replicate loci – sources and roles of DNA repair proteins
Chromosome instability as a driver of tumorigenesis, neurodegeneration and ageing
Exploitation of defects in chromosome maintenance in cancer treatment
The London Cell Cycle Club provides a venue for labs doing fundamental cell cycle research in model organisms to interact with those using mammalian cells to drive research in a more ‘translational’ direction.
In addition, the meeting provides a forum of expertise in cell cycle biology to critique new work, enabling new ideas to be ‘distilled’ prior to publication.
Encourage discussion in a relaxed atmosphere
Provide an opportunity for students and post-docs to present new and unpublished data
Inspire new collaborations within the UK and European cell cycle field
The specific goal for this meeting is to foster fruitful and creative interactions between researchers interested in applying these systems to genome engineering and related advances in a wide variety of organisms, together with scientists studying the basic biology of CRISPR-Cas and related bacterial defense systems.
This meeting will consist of six oral sessions, two poster sessions, and a panel discussion; In addition to invited speakers, a number of speakers will be selected from submitted abstracts.
Screens and Technology
Repairing DNA Breaks
Embryos and Germ Cells
The DNA damage response (DDR) is a complex signalling network including cell cycle checkpoints, DNA repair and DNA-damage tolerance pathways. The DDR is affected by, and impacts on, many cellular components and processes, including chromatin structure, DNA replication, transcription and cell cycle progression. Failure to properly respond to DNA damage leads to genomic instability, an underlining cause of various human syndromes and also associated with many age-related diseases, particularly cancer. Notably, it is becoming clear that the DDR is an attractive therapeutic target for cancer and other disease areas. The conference we propose will cover all the above topics in ways that will link detailed molecular mechanisms of the DDR and associated processes to human ageing, disease and therapeutic applications.
The aim of the CRCL International Cancer Symposium is to address fundamental issues of cancer biology from the molecular and biochemical determinants of cancer initiation and dissemination, to the impact of the tumour microenvironment and immunity, and to emphasise synergy between basic, clinical, and translational research. This meeting will also address how tumour cell plasticity contributes to enhanced tumour heterogeneity, sustained metastatic dissemination and escape from conventional and targeted therapies.
The ESMO Congress is the appointment in Europe for clinicians, researchers, patient advocates, journalists and the pharmaceutical industry from all over the world to get together, learn about the latest advances in oncology and translate science into better cancer patient care.
Research is at the heart of what we do. That’s why every year, FARF gathers prominent and aspiring FA researchers and clinicians together to share the latest updates in research and treatment and to form new collaborations. Over three days, participants attend sessions on a variety of topics, from basic science to clinical outcomes. Poster presentations are displayed throughout the conference in addition to two poster receptions. Because mentorship is a core value of ours, we organize a mentorship lunch during the conference to give young and early investigators the chance to mingle and learn from experts in a number of fields.
Research in the last two decades has revealed a surprising interplay between the DNA Damage Response (DDR) and RNA biology. It has been shown that transcription and RNA processing can interfere with DNA replication, thus becoming a serious potential threat to genome stability. Reciprocally, DNA lesions able to interfere with replication and transcription globally impact on different steps of RNA metabolism including RNA splicing and stability. In addition, recent observations suggest a potential important role of non-coding RNAs in the DDR. Finally, RNAs also act as key players regulating histones modifications, chromatin and chromosome organization that further influence all DNA metabolic processes from replication to repair. Altogether this recent research puts RNA as a key molecule in the whole network of DDR with both a potential positive and negative role in genome integrity, and DDR has emerged at the center of this complex interplay between DNA synthesis, transcription, RNA processing and chromatin, with major consequences for genomic instability. The aim of this Jacques Monod conference is to bring together experts from these different rapidly-changing fields in order to discuss the most recent results on these novel and important issues. In particular, we expect to discuss the following topics: a) Transcription and RNA as threats; b) Replication conflicts; c) Nuclear compartments and the DDR; d) DSB repair; e) The RNA in the DDR; e) Chromatin modifications in genome integrity, and f) Mechanisms of telomere integrity.
The meeting will host international leaders in the field to explore the links between genome stability and cancer. It will also provide a platform for earlier career researchers to present their work, share ideas, and expand their network.
Cellular transcription programmes undergo profound changes both during differentiation of healthy cells and during the malignant transformation of diseased cells. This modulation of transcriptional outputs is orchestrated by changes in chromatin structure that operate at different yet interconnected levels: they affect the arrangement of the genome in the nuclear space, the activity and accessibility of enhancers and other regulatory elements and the function of transcription factors, chromatin-associated proteins, enzymes acting on chromatin and RNA. Recent advances have expanded our understanding of the underlying molecular processes but also have raised many new questions.
The 5th TRR81 symposium on “Chromatin Changes in Differentiation and Malignancies” will provide a comprehensive view of the state-of-the-art and offer the opportunity for discussion with international leaders in the field.
The interdisciplinary conference will bring together leading experimental, computational and clinical scientists from across the world. The program will focus on ways to successfully apply and translate research findings into clinical practice, all the way from bench to bedside. We will talk about integrating clinical diagnostic techniques with genomics, e.g. in radiogenomics, and more generally about ways to accelerate the conversion of computational models into clinical routine.
Replication Initiation Factors and Origin Activation
Replication Timing and Origin Control in the Cell Cycle
Mechanisms for Replisome Assembly, Replication Fork Progression and Termination
Cellular Responses to Replication Fork Stalling and Checkpoint Activation
Integration of DNA Replication with Transcription
Effects of DNA Damage on Replication and Mutagenesis
Roles of Chromatin on Replication and Development
Effects of Dysfunctional DNA Replication on Genome Instability, Cancer and Other Diseases
The Meeting will bring together diverse groups covering a wide range of expertise in the field of lamins and nuclear envelope-related mechanisms in health and disease, from basic molecular mechanisms to human genetics and clinical science.
In this way, we expect to promote a dialogue that may better elucidate Nuclear Envelope disease mechanisms.
Large scale genome sequencing has led to deep catalogues of natural and disease-related human genetic variation. Unfortunately, we do not understand the functional implications of the vast majority of detected variants, and therefore cannot use them for healthcare or research. The rapid advances of CRISPR/Cas-based technologies and DNA synthesis now make it possible to modulate genomes with relative ease. These tools can help us understand how genetic variation impacts phenotype and answer important long-standing questions in biology that also impact human health, laying the foundations for precision medicine for heritable diseases and cancer treatment.
The programme will cover approaches that modulate the genome and its context at scale, from single nucleotides and genes to hundreds of growth environments. We will discuss (i) assays that focus on individual nucleotides in coding and non-coding regions to understand the effects of single mutations; (ii) focused- and genome-wide scrambling methods that assess the influence of changing genome structure and content; (iii) genome-wide knock-out, knock-down, and upregulation experiments to measure the phenotype when a gene is perturbed; (iv) interaction screens to uncover context-specificity of effects; and (v) small molecule treatments to understand their impact. Computational approaches are integral to all these topics, and will be covered by invited speakers, as well as sought for in submitted abstracts.
The conference will bring together biomedical researchers working on high throughput screening, genome engineering, and/or variant effect interpretation. We welcome abstracts on all major themes of this meeting to oral or poster presentations.
Oncology is a multi-disciplinary field, which is in need of many interdisciplinary methods to prognose, diagnose and treat cancer. Cancer, which is plaguing many low and middle Income Countries, is the second leading cause of death as per W.H.O. It is not a single disease to combat. There are more than 200 types of cancers, which need different treatments. It is alarming to know that deaths from cancer are also due to behavioural and dietary risks, such as: high body mass index; low fruit and vegetable intake; lack of physical activity; and use of tobacco and alcohol. Hence, there is a need for inter-disciplinary search globally. The conference provides a platform for cancer researchers, clinicians, oncologists, academicians and young scientists from all over the world to meet, share, update and comprehend the major problems encountered in oncology.
This two day research symposium on Genome Biology is organised by Birmingham Centre for Genome Biology (BCGB), which brings together researchers in the fields of Gene regulation, Epigenetics, DNA-repair, Genome stability, DNA-replication, Cancer Genetics and Computational/systems biology.
For over 60 years, preserving genomic integrity has been considered the cornerstone of cancer prevention, with many mutated genes being identified as being drivers of tumour progression. However, as many mutated genes ultimately encode for dysfunctional proteins, it has become clear that the preservation of protein integrity and the control of protein production are also essential in preventing malignant disease.
Many pathways exist to maintain appropriate rates of protein synthesis and to preserve proteome integrity. Control at the point of translation and post-translational modifications is central to the increased anabolism of tumours, and errors in these processes can cause critical cellular stress responses. Equally, cellular protein turnover by ubiquitin-mediated mechanisms and autophagy are also critical for the tumour cell viability and dependence on these pathways in mitigating oxidative damage and metabolic stress has uncovered a number of cancer vulnerabilities.
Ultimately, it is the aim of this conference to detail and integrate the different ways in which protein dynamics both protect against cancer and contribute to cancer maintenance. As these pathways can also have perturbations and greater dependencies in cancer, it is also a key theme of our conference to better understand how these pathways can be targeted for cancer therapy.
Yeasts are very versatile, model unicellular eukaryotes that have been extensively used for over a century to explore fundamental aspects of living systems. Annual gatherings of the British yeast community have taken place since the 1980s and the Microbiology Society have been pleased to incorporate the last two meetings in its annual Focused Meeting programme.
BYG 2019 will explore the theme of Discovery to Impact in which fundamental research themes are integrated with applied themes, including biotechnological applications of yeasts, yeasts as disease models, and pathogenic yeasts. The programme features an exciting range of keynote talks from acclaimed invited speakers and will also give early career stage yeast researchers the opportunity to present their recent research results through a series of posters and offered oral presentations. The meeting will also feature a varied social programme offering delegates plenty of opportunities to make new connections, discuss research projects and to strengthen relationships in the British yeast community.
Fundamental cellular processes, including metabolic cycles, chromatin biology, regulation of gene expression and control of quiescence
Yeasts as disease models
Biotechnological applications of yeasts
Health Horizons is a high caliber, two-day conference focusing on the future of the healthcare industry.
Over the previous 20 years we have seen a significant change in the healthcare industry. Small molecules have been pushed out of the blockbuster limelight by biologics. Decreasing sequencing cost has allowed more targeted R&D and the use of increasingly interdisciplinary data to influence prognosis has become standard practice. All of this points to a healthcare future with an increasingly personalized approach. But how will this future come together?
More details to follow:
The average age of the global population is increasing as a result of improved access to healthcare and changes in lifestyle. But, as life expectancy continues to increase, so too do the personal, socio-economic and financial burden of ageing-related diseases. Old age is the greatest risk factor for a number of chronic, progressive diseases, including diabetes, heart disease, cancer and neuro-degeneration. Over the past two decades, our understanding of the mechanisms of ageing at the molecular, cellular and organismal level has increased substantially. This improved knowledge now provides a realistic opportunity for us to intervene with the ageing process and to prevent or delay the onset of ageing-associated disorders through lifestyle modification and/or pharmacological and therapeutic interventions.
This conference brings together experts from diverse fields of research that explore the mechanisms of ageing and rejuvenation, from the perspective of genetics and epigenetics, cellular quality control and
senescence, stem cells, metabolism and brain function. The aim of the conference is to foster interactions and stimulate discussion of recent and unpublished advances in our understanding of the ageing process, and to explore new therapeutic opportunities for the rejuvenation and
preservation of organs and tissues to extend health span.
The 2019 Meeting will be our biggest and best meeting ever, and we have already secured 4 outstanding plenary speakers:
Agata Smogorzewska (Genome Maintenance) – Rockefeller University, New York, USA
Agnel Sfeir (Telomere Biology) – Skirball Institute of Biomolecular Medicine, New York University, Langone Medical Center, USA
Gerry Hanna (Senior Clinical Oncologist) – Centre for Cancer Research and Cell Biology, Belfast, Ireland.
Karlene Cimprich (Genome stability and DNA replication) – School of Medicine, Stanford University, Stanford, CA, USA
Considerable progress has been made in recent years in our understanding of the structure of chromosomes inside the nucleus or the bacteria, the role of long range contacts in gene regulation, the role of sub-chromosomal domains in controlling gene activation and single cell analysis. Similarly studies on the role of condensin and cohesins explain how long range contacts are stabilized and how chromosomes pair and segregate during cell division. However there is still an enormous gap in our understanding of the evolution of chromosomes structure, the physical processes that govern chromosome topology, chromosome condensation during mitosis, homology search during DNA repair or metaphase, the role of phase separation in the nucleus etc. We also do not fully understand how specific long range contacts are formed and resolved during the cell cycle, during differentiation or mitosis.
The time is ripe for the organisation of a dedicated scientific meeting to bring scientists investigating various aspects of chromosome biology, imaging, evolution, development and diseases together with physico-chemists and physicists interested in macromolecules and their assembly. We will also bring communities who do not mix frequently, those who study bacterial chromosomes, yeast and fungi with those who study invertebrates up to human and mouse cells and organisms.
The 2019 Cell Cycle Meeting in Trieste, Italy, will highlight the 'diversity in cell cycle control mechanisms’, exploring cell cycle control in different organisms, focusing on the similarities and differences in fundamental properties, to elucidate the wiring of cell cycle control networks in health and disease. This meeting will be the first of a biannual European meeting to alternate with the well-established Salk Cell Cycle meetings in California, USA. By coordinating with the Salk Cell Cycle meetings and inviting a large number of speakers from outside Europe the Cell Cycle Meeting in Trieste will draw a truly global attendance from the international cell cycle community (see our program). This will provide a larger international community with an opportunity to merge and share ideas.
PARP conferences are held since the 1970s, and the conferences were shuttled between Europe, USA and Japan. PARP2017 and PARP2019 aims to re-establish a series of bi-annual PARP conference series in Europe. PARP2019 follows the footsteps of the successful PARP2017 conference held in Budapest. The program of PARP2019 will cover the latest developments in basic PARP research, PARP-related pathophysiology and drug development.
Pint of Science brings scientists to discuss their latest research with you.
During May 20-22 2019, researchers across 24 countries will be sharing their discoveries with you in their local pub, bar or cafe.
Pint of Science is organised by a grass-root community of thousands of scientists across the world - come and meet us over a drink.
Multiple pathways and macromolecular complexes maintain the integrity of our genome. When these control and repair mechanisms fail, damage to DNA accumulates and promotes the development of cancer and other diseases. This meeting brings together research leaders in the field with a focus on the structural basis and molecular mechanisms.
The topic of the meeting “Mechanisms and Consequences of Chromosomal Translocations” covers the basic and translational underlying of chromosomal translocations in cancers. The aim of this meeting is to share the latest findings on chromosomal translocations, with major implications in our understanding of cancer etiology, onset, evolution and therapy resistance.
The meeting will be organized in three sessions:
Origins and mechanisms of chromosomal translocation formation
Toward a faithful modelling of chromosomal translocations
Diseases, functional consequences and treatment perspectives
Time will be dedicated to discussions with the aim to foster new ideas and collaborative projects. Finally, we will provide opportunities for oral and poster presentations for young scientists.