The Steve Jackson Laboratory Website
Transformative discoveries in genome and cellular integrity

Conferences

Apr
30
to May 4

Telomeres and Telomerase, Cold Spring Harbor, NY, USA

  • Cold Spring Harbor Laboratories (map)
  • Google Calendar ICS

We are pleased to offer the eleventh Cold Spring Harbor meeting on Telomeres & Telomerase to bring together a diverse group of scientists studying various molecular, cellular and genetic aspects of telomeres and telomerase biology.

Topics:

  • Regulation of Telomerase Expression & Activity

  • Telomerase Biogenesis & Structure

  • Telomere Replication

  • Mechanisms of ALT

  • Mechanisms of Telomere Protection

  • Telomere Protein Functions at Telomeres and Genomewide

  • Telomere Shortening & Mechanisms of Senescence

  • Telomeres & Human Health & Disease

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May
1
to May 4

EMBO Workshop Chromatin and Epigenetics, Heidelberg, Germany

Epigenetics refers to heritable change in gene expression that does not involve changes to the underlying DNA sequence. At least three systems including DNA methylation, histone modifications and non-coding RNAs (ncRNA) are considered to play fundamental roles in epigenetic regulation. Research over the last two decades has uncovered the role of epigenetics in a variety of human disorders and fatal diseases. Moreover influence of age, environment, lifestyle, and disease state on epigenetic states is being increasingly appreciated and actively studied.

This conference provides an international forum for cutting edge research in chromatin and epigenetics. It provides the "focal hub” for people to present their research and exchange ideas in a European venue. Renowned speakers will cover the latest advances in the field, including chromatin regulation, chromatin dynamics, signalling to chromatin, nuclear architecture and dynamics, developmental epigenetics, epigenomics, epigenetics and human diseases, genome stability, environmental epigenetics, and transgenerational inheritance.

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May
1
to May 4

18th International Ataxia-Telangiectasia Workshop (ATW2019), Houston, Texas, USA

  • Houston Methodist Research Institute (map)
  • Google Calendar ICS

The 18th International Ataxia-Telangiectasia Workshop (ATW2019) will bring together clinical and research scientists to explore the latest advances in understanding A-T and its treatments as well as the
underlying function of ATM in cancer, aging and other neurological diseases.

The scientific program features these six sessions:

* ATM and ATM-related Response Pathways
* ATM and Neurodegenerative Diseases
* ATM and Clinical Investigation of Human Diseases
* Chromatin Regulation in Genome Maintenance
* Canonical and Non-canonical Signaling and Repair Processes
* Mechanisms of DNA Damage Repair

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May
20
to May 21

"Mechanisms and Consequences of Chromosomal Translocations in Cancer" Meeting, Paris, France

The topic of the meeting “Mechanisms and Consequences of Chromosomal Translocations” covers the basic and translational underlying of chromosomal translocations in cancers. The aim of this meeting is to share the latest findings on chromosomal translocations, with major implications in our understanding of cancer etiology, onset, evolution and therapy resistance.

The meeting will be organized in three sessions:

  1. Origins and mechanisms of chromosomal translocation formation

  2. Toward a faithful modelling of chromosomal translocations

  3. Diseases, functional consequences and treatment perspectives

Time will be dedicated to discussions with the aim to foster new ideas and collaborative projects. Finally, we will provide opportunities for oral and poster presentations for young scientists.

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May
20
to May 22

Structural and Molecular Biology of the DNA Damage Response, Madrid, Spain

  • Spanish National Cancer Research Centre (map)
  • Google Calendar ICS

Multiple pathways and macromolecular complexes maintain the integrity of our genome. When these control and repair mechanisms fail, damage to DNA accumulates and promotes the development of cancer and other diseases. This meeting brings together research leaders in the field with a focus on the structural basis and molecular mechanisms.

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May
20
to May 22

Pint of Science Festival

Pint of Science brings scientists to discuss their latest research with you.

During May 20-22 2019, researchers across 24 countries will be sharing their discoveries with you in their local pub, bar or cafe.

Pint of Science is organised by a grass-root community of thousands of scientists across the world - come and meet us over a drink.

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May
20
to May 23

PARP 2019 "New avenues in basic and translational PARP research", Budapest, Hungary

  • Hungarian Academy of Sciences Research Centre for Natural Sciences (map)
  • Google Calendar ICS

PARP conferences are held since the 1970s, and the conferences were shuttled between Europe, USA and Japan. PARP2017 and PARP2019 aims to re-establish a series of bi-annual PARP conference series in Europe. PARP2019 follows the footsteps of the successful PARP2017 conference held in Budapest. The program of PARP2019 will cover the latest developments in basic PARP research, PARP-related pathophysiology and drug development.

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Jun
3
to Jun 6

2019 Cell Cycle Meeting, Trieste, Italy

  • Palazzo Congressi della Stazione Marittima di Trieste (map)
  • Google Calendar ICS

The 2019 Cell Cycle Meeting in Trieste, Italy, will highlight the 'diversity in cell cycle control mechanisms’, exploring cell cycle control in different organisms, focusing on the similarities and differences in fundamental properties, to elucidate the wiring of cell cycle control networks in health and disease. This meeting will be the first of a biannual European meeting to alternate with the well-established Salk Cell Cycle meetings in California, USA. By coordinating with the Salk Cell Cycle meetings and inviting a large number of speakers from outside Europe the Cell Cycle Meeting in Trieste will draw a truly global attendance from the international cell cycle community (see our program). This will provide a larger international community with an opportunity to merge and share ideas.

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Jun
4
to Jun 7

Francois Jacob Conference: Evolution, structure and function of chromosomes high order structure, Paris, France

Considerable progress has been made in recent years in our understanding of the structure of chromosomes inside the nucleus or the bacteria, the role of long range contacts in gene regulation, the role of sub-chromosomal domains in controlling gene activation and single cell analysis. Similarly studies on the role of condensin and cohesins explain how long range contacts are stabilized and how chromosomes pair and segregate during cell division. However there is still an enormous gap in our understanding of the evolution of chromosomes structure, the physical processes that govern chromosome topology, chromosome condensation during mitosis, homology search during DNA repair or metaphase, the role of phase separation in the nucleus etc. We also do not fully understand how specific long range contacts are formed and resolved during the cell cycle, during differentiation or mitosis.

The time is ripe for the organisation of a dedicated scientific meeting to bring scientists investigating various aspects of chromosome biology, imaging, evolution, development and diseases together with physico-chemists and physicists interested in macromolecules and their assembly. We will also bring communities who do not mix frequently, those who study bacterial chromosomes, yeast and fungi with those who study invertebrates up to human and mouse cells and organisms.

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Jun
17
to Jun 19

Australian Cell Cycle and DNA repair meeting, Sydney, Australia

The 2019 Meeting will be our biggest and best meeting ever, and we have already secured 4 outstanding plenary speakers:

Agata Smogorzewska (Genome Maintenance) – Rockefeller University, New York, USA

Agnel Sfeir (Telomere Biology) – Skirball Institute of Biomolecular Medicine, New York University, Langone Medical Center, USA

Gerry Hanna (Senior Clinical Oncologist) – Centre for Cancer Research and Cell Biology, Belfast, Ireland.

Karlene Cimprich (Genome stability and DNA replication) – School of Medicine, Stanford University, Stanford, CA, USA

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Jun
23
to Jun 26

Ageing, Health and Rejuvenation, Rotterdam, The Netherlands

  • De Doelen International Congress Centre Rotterdam, The Netherlands (map)
  • Google Calendar ICS

The average age of the global population is increasing as a result of improved access to healthcare and changes in lifestyle. But, as life expectancy continues to increase, so too do the personal, socio-economic and financial burden of ageing-related diseases. Old age is the greatest risk factor for a number of chronic, progressive diseases, including diabetes, heart disease, cancer and neuro-degeneration. Over the past two decades, our understanding of the mechanisms of ageing at the molecular, cellular and organismal level has increased substantially. This improved knowledge now provides a realistic opportunity for us to intervene with the ageing process and to prevent or delay the onset of ageing-associated disorders through lifestyle modification and/or pharmacological and therapeutic interventions.

This conference brings together experts from diverse fields of research that explore the mechanisms of ageing and rejuvenation, from the perspective of genetics and epigenetics, cellular quality control and
senescence, stem cells, metabolism and brain function. The aim of the conference is to foster interactions and stimulate discussion of recent and unpublished advances in our understanding of the ageing process, and to explore new therapeutic opportunities for the rejuvenation and
preservation of organs and tissues to extend health span.

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Jun
26
to Jun 27

Health Horizons 2019, Cambridge, UK

  • Cambridge Corn Exchange (map)
  • Google Calendar ICS

Health Horizons is a high caliber, two-day conference focusing on the future of the healthcare industry.

Over the previous 20 years we have seen a significant change in the healthcare industry. Small molecules have been pushed out of the blockbuster limelight by biologics. Decreasing sequencing cost has allowed more targeted R&D and the use of increasingly interdisciplinary data to influence prognosis has become standard practice. All of this points to a healthcare future with an increasingly personalized approach. But how will this future come together?

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Jun
26
to Jun 28

British Yeast Group: Discovery to Impact, Newcastle, UK

Yeasts are very versatile, model unicellular eukaryotes that have been extensively used for over a century to explore fundamental aspects of living systems. Annual gatherings of the British yeast community have taken place since the 1980s and the Microbiology Society have been pleased to incorporate the last two meetings in its annual Focused Meeting programme.

BYG 2019 will explore the theme of Discovery to Impact in which fundamental research themes are integrated with applied themes, including biotechnological applications of yeasts, yeasts as disease models, and pathogenic yeasts. The programme features an exciting range of keynote talks from acclaimed invited speakers and will also give early career stage yeast researchers the opportunity to present their recent research results through a series of posters and offered oral presentations. The meeting will also feature a varied social programme offering delegates plenty of opportunities to make new connections, discuss research projects and to strengthen relationships in the British yeast community.

Key topics

  • Fundamental cellular processes, including metabolic cycles, chromatin biology, regulation of gene expression and control of quiescence

  • Yeasts as disease models

  • Pathogenic yeasts

  • Biotechnological applications of yeasts

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Jul
4
to Jul 5

2nd Birmingham Symposium on Genome Structure and Function

  • University of Birmingham Medical School (map)
  • Google Calendar ICS

This two day research symposium on Genome Biology is organised by Birmingham Centre for Genome Biology (BCGB), which brings together researchers in the fields of Gene regulation, Epigenetics, DNA-repair, Genome stability, DNA-replication, Cancer Genetics and Computational/systems biology.

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Jul
25
to Jul 26

5th International Conference on Oncology and Research, Rome, Italy

Oncology is a multi-disciplinary field, which is in need of many interdisciplinary methods to prognose, diagnose and treat cancer. Cancer, which is plaguing many low and middle Income Countries, is the second leading cause of death as per W.H.O. It is not a single disease to combat. There are more than 200 types of cancers, which need different treatments. It is alarming to know that deaths from cancer are also due to behavioural and dietary risks, such as: high body mass index; low fruit and vegetable intake; lack of physical activity; and use of tobacco and alcohol. Hence, there is a need for inter-disciplinary search globally. The conference provides a platform for cancer researchers, clinicians, oncologists, academicians and young scientists from all over the world to meet, share, update and comprehend the major problems encountered in oncology.

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Sep
2
to Sep 5

9th UK Nuclear Envelope Meeting and 3rd International Meeting on Laminopathies Joint Meeting

  • King's College, Bush House (map)
  • Google Calendar ICS

The Meeting will bring together diverse groups covering a wide range of expertise in the field of lamins and nuclear envelope-related mechanisms in health and disease, from basic molecular mechanisms to human genetics and clinical science.

In this way, we expect to promote a dialogue that may better elucidate Nuclear Envelope disease mechanisms.

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Sep
3
to Sep 7

Eukaryotic DNA Replication & Genome Maintenance, Cold Spring Harbor, NY, USA

  • Cold Spring Harbor Laboratories (map)
  • Google Calendar ICS

Topics:

  • Replication Initiation Factors and Origin Activation

  • Replication Timing and Origin Control in the Cell Cycle

  • Mechanisms for Replisome Assembly, Replication Fork Progression and Termination

  • Cellular Responses to Replication Fork Stalling and Checkpoint Activation

  • Integration of DNA Replication with Transcription

  • Effects of DNA Damage on Replication and Mutagenesis

  • Roles of Chromatin on Replication and Development

  • Effects of Dysfunctional DNA Replication on Genome Instability, Cancer and Other Diseases

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Sep
9
to Sep 11

5th International TRR81 Symposium on "Chromatin Changes in Differentiation and Malignancies“, Bad Nauheim, Germany

  • Max Planck Institute for Heart and Lung Research (map)
  • Google Calendar ICS

Cellular transcription programmes undergo profound changes both during differentiation of healthy cells and during the malignant transformation of diseased cells. This modulation of transcriptional outputs is orchestrated by changes in chromatin structure that operate at different yet interconnected levels: they affect the arrangement of the genome in the nuclear space, the activity and accessibility of enhancers and other regulatory elements and the function of transcription factors, chromatin-associated proteins, enzymes acting on chromatin and RNA. Recent advances have expanded our understanding of the underlying molecular processes but also have raised many new questions.

The 5th TRR81 symposium on “Chromatin Changes in Differentiation and Malignancies” will provide a comprehensive view of the state-of-the-art and offer the opportunity for discussion with international leaders in the field.

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Sep
16
to Sep 20

Jacques Monod Conference "Genome Instability: when RNA meets chromatin" Roscoff, France

Research in the last two decades has revealed a surprising interplay between the DNA Damage Response (DDR) and RNA biology. It has been shown that transcription and RNA processing can interfere with DNA replication, thus becoming a serious potential threat to genome stability. Reciprocally, DNA lesions able to interfere with replication and transcription globally impact on different steps of RNA metabolism including RNA splicing and stability. In addition, recent observations suggest a potential important role of non-coding RNAs in the DDR. Finally, RNAs also act as key players regulating histones modifications, chromatin and chromosome organization that further influence all DNA metabolic processes from replication to repair. Altogether this recent research puts RNA as a key molecule in the whole network of DDR with both a potential positive and negative role in genome integrity, and DDR has emerged at the center of this complex interplay between DNA synthesis, transcription, RNA processing and chromatin, with major consequences for genomic instability. The aim of this Jacques Monod conference is to bring together experts from these different rapidly-changing fields in order to discuss the most recent results on these novel and important issues. In particular, we expect to discuss the following topics: a) Transcription and RNA as threats; b) Replication conflicts; c) Nuclear compartments and the DDR; d) DSB repair; e) The RNA in the DDR; e) Chromatin modifications in genome integrity, and f) Mechanisms of telomere integrity.

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Oct
7
to Oct 11

The DNA-damage response in cell physiology and disease, Attica, Greece

The DNA damage response (DDR) is a complex signalling network including cell cycle checkpoints, DNA repair and DNA-damage tolerance pathways. The DDR is affected by, and impacts on, many cellular components and processes, including chromatin structure, DNA replication, transcription and cell cycle progression. Failure to properly respond to DNA damage leads to genomic instability, an underlining cause of various human syndromes and also associated with many age-related diseases, particularly cancer. Notably, it is becoming clear that the DDR is an attractive therapeutic target for cancer and other disease areas. The conference we propose will cover all the above topics in ways that will link detailed molecular mechanisms of the DDR and associated processes to human ageing, disease and therapeutic applications.

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Nov
13
to Nov 15

A Century of Genetics, Celebrating 100 years of Genetics in Edinburgh and the Genetics Society in the UK, Edinburgh, UK

  • Royal College of Physicians (map)
  • Google Calendar ICS

2019 is coincidentally the centenary of both the Genetics Society and the origins of the Roslin Institute and the Institute of Evolutionary Biology, University of Edinburgh. A joint scientific celebratory meeting will be held from 13-15th November 2019, Edinburgh.

Excellent scientific, public outreach and social programmes are being formulated.

The scientific meeting will focus on the work of prominent scientists who have connections with Edinburgh.

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Feb
20
12:30 PM12:30

4th DNA Repair/Replication Structures & Cancer conference, Nassau, Bahamas

This conference will focus on structural and mechanistic insights into dynamic protein, chromatin, DNA and RNA complexes acting in DNA repair and its interface with DNA replication and transcription events relevant to cancer. This fundamental information will be pivotal for the accurate interpretation of cancer clinical data, design of clinical trials, prognosis, etiology and improving the currently 1/20 low success rate for oncology drug clinical trials. Informative talks and poster sessions along with vibrant discussions will foster productive interactions and collaborations.

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Oct
5
to Oct 8

3rd Chromosomal Instability as a Driver of Human Disease conference, Lisbon, Portugal

This conference is a continuation of the DNA Replication as a Source of DNA Damage series.

The maintenance of genome integrity is critical for the suppression of several pathological disorders in humans, including cancer, infertility and neurodegeneration. Moreover, the accumulation of unrepaired errors in DNA is commonly cited as a likely cause of tissue and organismal ageing. Destabilization of the genome can occur as a result of several cell intrinsic or extrinsic factors, including errors arising during DNA replication or chromosome segregation, as well as exposure of cells to agents that induce DNA damage. In this conference, we aim to bring together scientists studying DNA replication, DNA repair and chromosome segregation with those interested in how chromosomal instability can influence human pathology. Moreover, we aim to show how high throughput and high content screening methods can be used as a discovery tool both for basic science applications and to identify potential therapeutic modalities.

Key Sessions

  • Pathways for repair of DNA damage and disrupted DNA replication forks

  • Screening tools for analysis of genome maintenance pathways and for development of new therapeutics

  • Chromosome fragility caused by difficult-to-replicate loci – sources and roles of DNA repair proteins

  • Chromosome instability as a driver of tumorigenesis, neurodegeneration and ageing

  • Exploitation of defects in chromosome maintenance in cancer treatment

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Apr
8
to Apr 11

33rd Genes and Cancer Meeting, Cambridge, UK

‘Genes and Cancer’ is a broad-based research meeting focusing on basic and translational cancer research. The meeting is one of the UK and Europe’s best cancer research meetings and the meeting is now in its 33rd year. This year’s event is focused on four main research themes.

‘Gene Regulation in Cancer’

‘Ubiquitin Signalling and Inflammation’

‘Tumour Metabolism’

‘Model Organisms in Cancer Research’.

In addition to these 4 themes there will be a Keynote lecture and short talks will be chosen from submitted abstracts (including short talks for junior principal investigators and short talks for post-docs/students). A poster session also forms part of the programme which runs concurrently with a trade exhibition. A number of prizes are awarded for the best posters. The main aim of the meeting is to bring together young scientists with some of the world’s leaders in cancer research in an informal environment that maximizes interaction between speakers and delegates. It is hoped that the format and atmosphere at the conference will serve as an inspiration to those at the early stages of their scientific careers.

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Apr
7
to Apr 11

EMBO Workshop "Genome Dynamics in the Neurosciences and Aging", Israel

Genome stability, which is essential for cellular homeostasis, relies primarily on the DNA damage response network. Genome stability is also essential to the proper functioning of the nervous system, evidenced by the prominence of neurodegeneration in many genome instability syndromes. Recent evidence suggests a broader role of genome stability in human health, one that affects aging and common chronic morbidities. Genome Dynamics in Neuroscience and Aging (GDNA) is an interdisciplinary EMBO workshop bringing together researchers of the DNA damage response, neuroscience, aging, cell senescence, mitochondrial function, and metabolism to discuss the links between genome stability and these aspects of human physiology, and the impact of genome instability on them and on longevity.

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Apr
2
to Apr 3

2019 Research and Innovation ELRIG Conference, Cambridge, UK

The overall meeting focus for 2019 will be "innovations for the future of drug discovery" comprising the following four main sessions:

  1. Innovating the future of rationale drug design

  2. Where are new drug target hypotheses coming from?

  3. Therapeutic approaches of the future

  4. Next generation in vitro models for drug efficiency & safety

This meeting is organised by ELRIG, European Laboratory Research and Innovation Group

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Mar
19
1:00 PM13:00

London Cell Cycle Club Meeting, London, UK

The London Cell Cycle Club provides a venue for labs doing fundamental cell cycle research in model organisms to interact with those using mammalian cells to drive research in a more ‘translational’ direction.

In addition, the meeting provides a forum of expertise in cell cycle biology to critique new work, enabling new ideas to be ‘distilled’ prior to publication.

Our aims

  • Encourage discussion in a relaxed atmosphere

  • Provide an opportunity for students and post-docs to present new and unpublished data

  • Inspire new collaborations within the UK and European cell cycle field

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Mar
7
to Mar 8

Medicine at the Crick "Biotherapies in cancer: towards improving clinical outcomes", The Francis Crick Institute, London

  • The Francis Crick Institute, London (map)
  • Google Calendar ICS

Our new Medicine at the Crick event series showcases major advances in biomedical science and raises awareness of the medical implications of major scientific advances amongst the Crick and wider UK biomedical community. Each event comprises a series of short talks, one or two keynote lectures and a panel discussion.

Our third event in the series, Biotherapies in cancer: towards improving clinical outcomes, will review the profound opportunities of CAR-T cell therapy, adoptive cellular immunotherapies and checkpoint inhibitor therapy in the management of haematologic and metastatic solid tumours. These Immunotherapies, by leveraging the patient's immune system, are transforming clinical care, resulting in prolonged survival and even cancer cures in a previously palliative setting. The event will review recent breakthroughs in the field, challenges and opportunities in the translation of scientific findings into the clinic and the promise of leveraging adaptive cellular therapies to tackle cancer clonal evolution for patient benefit.

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Mar
7
to Mar 8

Cancer Research UK Cambridge Institute International Symposium 2019, Cambridge, UK

  • Cancer Research UK Cambridge Institute (map)
  • Google Calendar ICS

Radical approaches to cancer prevention

Each year we welcome experts from across world and, as in previous years, we expect the meeting to fill up fast so book early to avoid disappointment!

We’ll be covering a wide range of topics including:

  • Using new technology to reduce and prevent disease.

  • Training the immune system.

  • Preventing cancer through medical intervention.

  • Preventing cancer through lifestyle and policy.

See the scientific programme for the full list of speakers, include keynote talks from Nobel laureate Prof Harald zur Hausen, Prof Mette Kalager and Dr Christopher P Wild.

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Feb
27
to Feb 28

CRISPR in Drug Discovery 2019: From Targets to Therapeutics, Oxford, UK

Genome Engineering, including Zinc-finger, TALEN and most recently CRISPR/Cas9, has become a powerful tool in the drug discovery pipeline. This meeting will focus on the application of genome engineering to identify novel drug targets through large scale CRISPR based functional genomics studies, target validation in developing advanced cellular and in vivo disease models, and the pioneering applications in therapeutic genome editing. A current perspective of the applications of these rapidly developing technologies with a focus on drug discovery applications will be the meeting’s focus.

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Feb
27
to Mar 1

AEK Cancer Congress "Translating Cancer Biology: From Basic Mechanisms to Therapeutic Exploitation", Heidelberg, Germany

  • EMBL Advanced Training Centre (map)
  • Google Calendar ICS

The AEK Cancer Congress is a medium size conference with around 500 participants. It is funded by the German Cancer Society (this time with additional support of the German Research Foundation) and will be held in 2019 under the theme “Translating Cancer Biology: From Basic Mechanism to Therapeutic Exploitation”.

The conference comprises eight sessions on seven key topics of cancer biology: Cancer Immunology & Immunotherapy, Targeting Myc and Ras, Replicative Stress and DNA Damage Response, Cellular Senescence in Cancer, Metastasis, Novel Tools and Model Systems in Cancer Research and Tumor Microenvironment.

Besides 21 talks given by internationally renowned leaders in these fields, a total of 16 abstract talks to be selected will give students, postdocs and junior faculty the chance to present their latest research. In addition, the best posters will be presented as “Flash Talks”.

We particularly would like to encourage students and postdocs to attend the conference and offer special registration rates for them. In addition, there will be travel bursaries for young investigators.

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Feb
23
to Feb 26

3rd Exploring DNA Repair Pathways as Targets for Cancer Therapy Conference, Nassau, Bahamas

Defect in DNA damage repair and checkpoint control is the underlying mechanism for tumorigenesis, since it allows the accumulation of multiple genetic alternations, which are essential for the initiation of tumorigenesis. This has been clearly illustrated to be the cause of several human cancer-prone syndromes and also revealed by recent human genome studies. On the other hand, defective DNA repair and checkpoint activation also make cancer cells more vulnerable for particular DNA damaging agents or inhibitors that specifically disrupt some of these checkpoint pathways. With the increasing understanding of defects in DNA repair and checkpoint control in tumorigenesis, there are extensive interests in exploring these deficiencies, especially taking advantage of the synthetic lethality concept and targeting particular DNA repair and checkpoint pathways for cancer therapy. The purpose of this conference is to bring together basic, translational and clinical investigators and discuss the current and future directions, opportunities and obstacles in the development of these anti-cancer modalities and how to best apply these concepts in clinical practice.

  • Key Sessions
  • Highlight recent advances in the field of DNA damage repair
  • Identify novel targets in DNA repair and checkpoint pathways
  • Explore the concept of synthetic lethality for cancer treatment
  • Assess the therapeutic potential of new anti-cancer modalities
  • Learn mechanisms of therapeutic resistance and ways to improve cancer therapy
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Feb
13
to Feb 16

6th Nucleic Acids Conference, Nassau, Bahamas

This meeting is a continuation of the Zing Conferences Nucleic Acids series.

The key role of nucleic acids is to encode and process genetic information at a molecular level. DNA is the genetic library of the cell, while RNA transports, translates and controls the expression of that information. DNA must be copied with unprecedented accuracy once every cell cycle. It is under constant endogenous and environmental onslaught, and a variety of repair pathways are necessary to maintain the integrity of the genetic blueprint. DNA is the only cellular molecule for which repair occurs to a significant extent. DNA undergoes recombination, a kind of molecular cut and re-join that creates diversity to facilitate evolution, as well as providing an important repair pathway. In eukaryotes something like 2m DNA is packaged into chromosomes so that it packs into the cell nucleus with a diameter of just 6 µm, while remaining accessible to the cellular machinery that reads out its genetic information. 

RNA is the dynamic worker bee of genetics to the DNA's queen, and an extremely versatile molecule. In the central dogma RNA is the messenger (mRNA) and translators (tRNA) that passes the information between the DNA genome and the protein synthesis machinery, yet it does much, much more. In translation of the genetic information it forms the architectural framework and catalytic center of the ribosome. In eukaryotic cells the pre-mRNA must be processed by the precise removal of intervening sequences (introns), carried out by a large and dynamic RNA-protein machine called the spliceosome. Increasingly we realize that RNA is also involved in critical and complex regulatory processes. RNA can act as a molecular switch responding to small molecules in order to control gene expression. Indeed while most of the genomic DNA does not encode proteins, almost all of it is transcribed into RNA. We are only just beginning the long journey of understanding what all this non-coding RNA is doing - it is very much the 'dark matter' of biology ! Lastly RNA can also accelerate chemical reactions by a million fold or more in the manner of an enzyme. This is very likely of key significance in the origin of life on the planet more than three billion years ago.

Understanding processes involving DNA and RNA at the molecular and chemical level is the central theme of this conference, with a marked structural and mechanistic perspective. The meeting will provide a platform for researchers to discover and discuss the latest advances in the field of nucleic acids, DNA and RNA, with exciting opportunities to share and receive feedback on unpublished data.

Discussion topics will include;

  • DNA replication
  • DNA repair
  • DNA recombination
  • RNA structure and function
  • Translation and the ribosome
  • Silencing
  • CRISPR/Cas and genome editing
  • Gene regulation and riboswitches
  • RNA catalysis
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Feb
10
to Feb 15

Gordon Research Conference, "Genome Maintenance: Mechanisms of Repair, Consequences of Failure for Human Disease and Opportunities for Therapeutic Intervention", Ventura, California, USA

Our genome is constantly challenged by environmental and endogenous sources of DNA damage and replication stress. A multitude of DNA repair and DNA damage response mechanisms successfully operate to maintain genome stability. However, failures do happen resulting in diseases ranging from rare developmental and premature aging syndromes to common cancers. This Mammalian DNA Repair GRC and associated GRS will bring together diverse researchers studying the mechanisms that maintain genome stability and the consequences for human health when these mechanisms fail. In addition, the conference will explore opportunities that DNA repair and signaling networks provide for therapeutic intervention, and discuss how we can harness these DNA metabolism pathways for genome editing.

A diverse cadre of invited speakers will present new discoveries, approaches, and concepts at the frontier of mammalian DNA repair. Additionally, multiple speakers will be selected from abstract submissions and vigorous poster sessions will provide opportunities for sharing participant’s latest research. This GRC will continue a strong tradition of welcoming young scientists, connecting new and senior members of the field, and engaging all participants in discussion through an open atmosphere of scientific exchange.

Applications from investigators interested in all aspects of DNA metabolism and genome stability from basic mechanisms to clinical intervention are encouraged. Trainees are encouraged to attend this GRC and the associated GRS.

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Feb
9
to Feb 10

Gordon Research Seminar, "Genome Maintenance: Mechanisms of Repair, Consequences of Failure for Human Disease and Opportunities for Therapeutic Intervention", Ventura, California, USA

The Gordon Research Seminar (GRS) on Mammalian DNA repair is a unique forum for graduate students and post-doctoral researchers, representing a broad range of expertise and interests, to present and exchange new data and leading-edge ideas. The meeting will take place in a relaxed and highly engaging environment aimed to empower young scientists to communicate ideas among their peers, and will also include opportunities to network and interact with invited experts and senior scientists from various career paths and stages of professional development.

This Mammalian DNA Repair GRS will bring together early career scientists studying the cellular DNA signalling and repair mechanisms that maintain genome stability. Our genome is constantly being damaged from external and internal sources. To combat this, and to prevent genome instability, cells have evolved a multitude of efficient DNA repair pathways that detect, signal and repair DNA damage. The importance of these DNA repair pathways is highlighted by the existence of numerous human diseases that are associated with mutations in DNA repair factors. This meeting will encourage stimulating discussions on unpublished research and recent developments in the field of mammalian DNA repair, particularly highlighting new successes new opportunities, and also discussing the consequences associated with a failure to respond and/or repair DNA damage.

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Jan
13
to Jan 18

DNA Replication and Genome Instability: From Mechanism to Disease, Snowbird, Utah, USA

This meeting will bring together scientists studying the most fundamental aspects of DNA replication and recombination, the organization and regulation of these processes at the cellular and molecular level, and their links to human disease. The aim is to disseminate the latest progress in this area; provide young scientists with the opportunity to present their work in a short talk or poster format; discuss the challenges and opportunities in developing basic research knowledge for the treatment of disease, and discuss the relevance of emerging work in other fields to genome instability and replication stress. Through talks and specialized workshops led by leaders in the field, the meeting will cover single-molecule to cellular and genome-level studies, providing an integrated view of the relationship between DNA replication, recombination and genome instability.

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Nov
22
to Nov 23

Young Life Scientists’ Symposium "Genome Integrity: a Lifetime's Challenge", Montpellier, France

  • Campus Arnaud de Villeneuve (map)
  • Google Calendar ICS

Young Life Scientists’ Symposia (YLS) are one day scientific conferences supported by the Biochemical Society and organized by PhD students and post-docs for their peers. These events promote networking and professional development through social events and careers sessions, as well as scientific talks and poster sessions.

The symposium focuses on the cellular processes that take place at the level of the genetic material, from the generation of gametes to the development of a mature organism and its decline. The symposium’s scientific programme is organised into three sessions of talks and two poster sessions under the general theme of “Genome Integrity: a lifetime's challenge”.

Session 1: Genome transmission: getting prepared for life
Session 2 : Cellular processes: coordinating life
Session 3 : Ageing and Disease: staying alive
Inspirational Talks : A life dedicated to science

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Nov
11
to Nov 15

From Rare to Care: Discovery, Modeling and Translation of Rare Diseases, Vienna, Austria

Work over the past 30 years has resulted in the identification of genes for ~50% of the estimated 7,000 rare genetic diseases; it is predicted that most of the remaining disease genes will be identified in the next 10 years. Approximately 500 medicinal products are currently on the market for rare diseases. The accelerating pace of rare disease gene identification means, in effect, an almost commensurate increase in molecularly defined, readily diagnosable, but nonetheless poorly understood and untreatable, diseases. This meeting will examine the current and future bottlenecks to gene discovery, disease modeling, and therapeutic approaches and suggest strategies to enable progress in this regard. Ultimately, successful deployment of precision medicine for rare diseases will inform such approaches more broadly.

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Nov
4
to Nov 6

2018 NCRI Cancer Conference, Glasgow, UK

The NCRI Cancer Conference is the UK’s largest forum showcasing the latest advances in cancer research. The Conference provides a platform for researchers, clinicians, people affected by cancer and industry representatives to come together to discuss, present and showcase high-quality research. Informative and interactive educational sessions attract over 1,500 delegates each year and create the ideal setting to establish new collaborations with key stakeholders in cancer research.

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Oct
10
to Oct 13

RNA and genome maintenance: Cooperation and conflict management, Mainz, Germany

  • Institute of Molecular Biology gGmbH (map)
  • Google Calendar ICS

Genomes of living organisms are exposed to damage arising from different sources. To maintain genome integrity, cells and organisms have evolved elaborate mechanisms and signaling pathways that regulate different processes including DNA repair and cell cycle. Recent findings highlighted the intricate interplay between genome stability maintenance and RNA metabolism: Transcription can interfere with DNA replication and thus pose a serious threat to genome stability. Conversely, DNA damage activates signaling pathways that globally affect transcription, splicing and RNA stability. Moreover, non-coding RNA and RNA-binding proteins play an integral part in DNA repair and DNA damage response. This EMBO Workshop will gather established scientists and junior researchers that study the mutual interactions between the DNA damage response and RNA metabolism. The workshop will provide a forum for open and inspiring discussions between the scientists that shaped and the ones that recently joined this exciting and rapidly progressing field on the following topics:

  • Replication-transcription conflicts and transcription-associated DNA damage
  • RNA-binding proteins in genome stability maintenance
  • Non-coding RNA in the DNA damage response
  • Interplay between the DNA damage response and RNA metabolism
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Sep
30
to Oct 4

Protein Signaling - from pathways to networks, Copenhagen, Denmark

Protein signaling is the cells most important regulatory mechanism to appropriately respond to internal and external cues. This is afforded by a wealth of posttranslational modifications, which expands the functional diversity of the human proteome by several orders of magnitude. Most therapeutic drugs are directed against proteins, or are proteins themselves, and protein-related technologies promise to revolutionize our understanding of the complex wiring of biological systems. This meeting will bring together world-leading researchers in the area of protein signaling with a focus on protein-driven mechanisms that are relevant to physiology and disease. The meeting will also have a strong emphasis on the emerging single cell and single-molecule technologies as well as on the advances in proteomics, network biology and structural biology. Finally, an important focus will be bridging fundamental discoveries to clinical relevant applications.

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Sep
23
to Sep 26

The DNA Polymerases Meeting, Leiden, The Netherlands

We aim to bring together, in an informal atmosphere, an outstanding and diverse group of scientists working at the forefront of this field. The meeting sessions will cover all relevant aspects of DNA polymerases, including their structure and biochemistry, their genetics, their roles in mutagenesis, fitness and pathologies as well as their applications to molecular biology and medicine.  With the goal of stimulating cross-fertilization we are also inviting a number of speakers from fields related to the DNA polymerase field. 

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Sep
17
to Sep 21

EMBO Workshop "DNA Replication, Chromosome Segregation and Fate Decisions", Kyllini, Greece

Bringing together scientists working with eukaryotes, bacteria and archaea, and employing interdisciplinary methodological approaches, this EMBO Workhshop aims to decipher the common pathways which ensure genome maintenance during the cell division cycle of all organisms and how they may affect cell fate choices.

Topics will include:

  • Replication origins
  • Replisome structure and function
  • Replication-transcription collisions and arrested forks
  • Replication timing
  • DNA and chromosome dynamics
  • 3D nuclear organization, chromatin structure and epigenetic regulation
  • Chromosome condensation and cohesion
  • Chromosome segregation mechanisms and regulation
  • Coordination of replication and segregation
  • Links with cell fate choices
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Sep
6
to Sep 8

Jena Ageing Meeting, Jena, Germany

  • Friedrich Schiller University (map)
  • Google Calendar ICS

Aging is the single biggest risk factor for the development of organ dysfunction and diseases. Even though under debate, there is a strong association between stem division rates and declines in stem cell function possibly impinging on the selection of mutant stem cells in aging, impairments in tissue maintenance and disease development. There are several new therapeutic targets and basic concepts on the causes and consequences of stem cell and organism aging that will be discussed at this meeting.

Principal themes and objectives of the meeting

A unifying theme of this meeting will be the interaction of researchers that study basic principles of stem cell and tissue maintenance in aging. The meeting will focus on basic molecular and genetic processes that affect genetic and epigenetic stability, protein homeostasis, and metabolic processes thereby impairing the functionality and self renewal of stem cells, and organ maintenance.

The meeting will focus on basic mechanisms as well as innovative animal models and humanized models of aging. In addition, there will be fields such as stem cell niches and circulatory factors, developmental biology, cell plasticity, and clonal dominance. These processes all have tremendous impact on our understanding of organism aging.

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Sep
5
to Sep 8

Principles of Chromosome Structure and Function, EMBL Heidelberg, Germany

Topics

  • Chromosome dynamics
  • Nuclear architecture
  • DNA transcription, replication and segregation
  • Hi-C and polymer modelling
  • Molecular mechanisms
  • Structural and functional imaging approaches
  • Genome integrity
  • Chromatin

Why attend?

This interdisciplinary symposium will highlight exciting new insights into the molecular principles that govern the functional framework of genomes in space and time. The meeting program will cover all levels of organisational complexity, from DNA to chromosomes, and in model systems ranging from bacteria to humans. A particular highlight will be the integration of discoveries made in different disciplines, including cell and molecular biology, biophysics, modelling, structural biology and biochemistry.

Aims

This symposium aims to bring together scientists from different disciplines working at the forefront of chromosome biology to discuss the most recent advances in the field. By combining efforts from biology, physics and chemistry, the programme will open new horizons for future research in this exciting area of the life sciences.

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