The Steve Jackson Laboratory Website
Transformative discoveries in genome and cellular integrity

Conferences

Sep
2
to Sep 4

CRISPR and beyond: perturbations at scale to understand genomes, Hinxton, Cambridge, UK

Large scale genome sequencing has led to deep catalogues of natural and disease-related human genetic variation. Unfortunately, we do not understand the functional implications of the vast majority of detected variants, and therefore cannot use them for healthcare or research. The rapid advances of CRISPR/Cas-based technologies and DNA synthesis now make it possible to modulate genomes with relative ease. These tools can help us understand how genetic variation impacts phenotype and answer important long-standing questions in biology that also impact human health, laying the foundations for precision medicine for heritable diseases and cancer treatment.

The programme will cover approaches that modulate the genome and its context at scale, from single nucleotides and genes to hundreds of growth environments. We will discuss (i) assays that focus on individual nucleotides in coding and non-coding regions to understand the effects of single mutations; (ii) focused- and genome-wide scrambling methods that assess the influence of changing genome structure and content; (iii) genome-wide knock-out, knock-down, and upregulation experiments to measure the phenotype when a gene is perturbed; (iv) interaction screens to uncover context-specificity of effects; and (v) small molecule treatments to understand their impact. Computational approaches are integral to all these topics, and will be covered by invited speakers, as well as sought for in submitted abstracts.

The conference will bring together biomedical researchers working on high throughput screening, genome engineering, and/or variant effect interpretation. We welcome abstracts on all major themes of this meeting to oral or poster presentations.

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Sep
2
to Sep 5

9th UK Nuclear Envelope Meeting and 3rd International Meeting on Laminopathies Joint Meeting

  • King's College, Bush House (map)
  • Google Calendar ICS

The Meeting will bring together diverse groups covering a wide range of expertise in the field of lamins and nuclear envelope-related mechanisms in health and disease, from basic molecular mechanisms to human genetics and clinical science.

In this way, we expect to promote a dialogue that may better elucidate Nuclear Envelope disease mechanisms.

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Sep
3
to Sep 7

Eukaryotic DNA Replication & Genome Maintenance, Cold Spring Harbor, NY, USA

  • Cold Spring Harbor Laboratories (map)
  • Google Calendar ICS

Topics:

  • Replication Initiation Factors and Origin Activation

  • Replication Timing and Origin Control in the Cell Cycle

  • Mechanisms for Replisome Assembly, Replication Fork Progression and Termination

  • Cellular Responses to Replication Fork Stalling and Checkpoint Activation

  • Integration of DNA Replication with Transcription

  • Effects of DNA Damage on Replication and Mutagenesis

  • Roles of Chromatin on Replication and Development

  • Effects of Dysfunctional DNA Replication on Genome Instability, Cancer and Other Diseases

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Sep
5
to Sep 6

Cancer Biology and Treatment: From computational models to treatment decisions, Cambridge, UK

The interdisciplinary conference will bring together leading experimental, computational and clinical scientists from across the world. The program will focus on ways to successfully apply and translate research findings into clinical practice, all the way from bench to bedside. We will talk about integrating clinical diagnostic techniques with genomics, e.g. in radiogenomics, and more generally about ways to accelerate the conversion of computational models into clinical routine.

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Sep
9
to Sep 11

5th International TRR81 Symposium on "Chromatin Changes in Differentiation and Malignancies“, Bad Nauheim, Germany

  • Max Planck Institute for Heart and Lung Research (map)
  • Google Calendar ICS

Cellular transcription programmes undergo profound changes both during differentiation of healthy cells and during the malignant transformation of diseased cells. This modulation of transcriptional outputs is orchestrated by changes in chromatin structure that operate at different yet interconnected levels: they affect the arrangement of the genome in the nuclear space, the activity and accessibility of enhancers and other regulatory elements and the function of transcription factors, chromatin-associated proteins, enzymes acting on chromatin and RNA. Recent advances have expanded our understanding of the underlying molecular processes but also have raised many new questions.

The 5th TRR81 symposium on “Chromatin Changes in Differentiation and Malignancies” will provide a comprehensive view of the state-of-the-art and offer the opportunity for discussion with international leaders in the field.

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Sep
16
to Sep 20

Jacques Monod Conference "Genome Instability: when RNA meets chromatin" Roscoff, France

Research in the last two decades has revealed a surprising interplay between the DNA Damage Response (DDR) and RNA biology. It has been shown that transcription and RNA processing can interfere with DNA replication, thus becoming a serious potential threat to genome stability. Reciprocally, DNA lesions able to interfere with replication and transcription globally impact on different steps of RNA metabolism including RNA splicing and stability. In addition, recent observations suggest a potential important role of non-coding RNAs in the DDR. Finally, RNAs also act as key players regulating histones modifications, chromatin and chromosome organization that further influence all DNA metabolic processes from replication to repair. Altogether this recent research puts RNA as a key molecule in the whole network of DDR with both a potential positive and negative role in genome integrity, and DDR has emerged at the center of this complex interplay between DNA synthesis, transcription, RNA processing and chromatin, with major consequences for genomic instability. The aim of this Jacques Monod conference is to bring together experts from these different rapidly-changing fields in order to discuss the most recent results on these novel and important issues. In particular, we expect to discuss the following topics: a) Transcription and RNA as threats; b) Replication conflicts; c) Nuclear compartments and the DDR; d) DSB repair; e) The RNA in the DDR; e) Chromatin modifications in genome integrity, and f) Mechanisms of telomere integrity.

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Sep
19
to Sep 22

Fanconi Anemia Scientific Symposium, Chicago, USA

Research is at the heart of what we do. That’s why every year, FARF gathers prominent and aspiring FA researchers and clinicians together to share the latest updates in research and treatment and to form new collaborations. Over three days, participants attend sessions on a variety of topics, from basic science to clinical outcomes. Poster presentations are displayed throughout the conference in addition to two poster receptions. Because mentorship is a core value of ours, we organize a mentorship lunch during the conference to give young and early investigators the chance to mingle and learn from experts in a number of fields.

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Sep
27
to Oct 1

ESMO Congress 2019, Barcelona, Spain

The ESMO Congress is the appointment in Europe for clinicians, researchers, patient advocates, journalists and the pharmaceutical industry from all over the world to get together, learn about the latest advances in oncology and translate science into better cancer patient care.

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Oct
2
to Oct 4

4th International Cancer Symposium, Lyon, France

The aim of the CRCL International Cancer Symposium is to address fundamental issues of cancer biology from the molecular and biochemical determinants of cancer initiation and dissemination, to the impact of the tumour microenvironment and immunity, and to emphasise synergy between basic, clinical, and translational research. This meeting will also address how tumour cell plasticity contributes to enhanced tumour heterogeneity, sustained metastatic dissemination and escape from conventional and targeted therapies.

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Oct
7
to Oct 11

The DNA-damage response in cell physiology and disease, Attica, Greece

The DNA damage response (DDR) is a complex signalling network including cell cycle checkpoints, DNA repair and DNA-damage tolerance pathways. The DDR is affected by, and impacts on, many cellular components and processes, including chromatin structure, DNA replication, transcription and cell cycle progression. Failure to properly respond to DNA damage leads to genomic instability, an underlining cause of various human syndromes and also associated with many age-related diseases, particularly cancer. Notably, it is becoming clear that the DDR is an attractive therapeutic target for cancer and other disease areas. The conference we propose will cover all the above topics in ways that will link detailed molecular mechanisms of the DDR and associated processes to human ageing, disease and therapeutic applications.

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Oct
10
to Oct 13

Genome Engineering: Frontiers of CRISPR/Cas, CSHL, New York, USA

  • Cold Spring Harbor Laboratory (map)
  • Google Calendar ICS

The specific goal for this meeting is to foster fruitful and creative interactions between researchers interested in applying these systems to genome engineering and related advances in a wide variety of organisms, together with scientists studying the basic biology of CRISPR-Cas and related bacterial defense systems.
This meeting will consist of six oral sessions, two poster sessions, and a panel discussion; In addition to invited speakers, a number of speakers will be selected from submitted abstracts.

Topics:

  • CRISPR Biology

  • Screens and Technology

  • Cell Engineering

  • Repairing DNA Breaks

  • Embryos and Germ Cells

  • Gene Therapy

  • Plants

  • Technology II

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Nov
13
to Nov 15

A Century of Genetics, Celebrating 100 years of Genetics in Edinburgh and the Genetics Society in the UK, Edinburgh, UK

  • Royal College of Physicians (map)
  • Google Calendar ICS

2019 is coincidentally the centenary of both the Genetics Society and the origins of the Roslin Institute and the Institute of Evolutionary Biology, University of Edinburgh. A joint scientific celebratory meeting will be held from 13-15th November 2019, Edinburgh.

Excellent scientific, public outreach and social programmes are being formulated.

The scientific meeting will focus on the work of prominent scientists who have connections with Edinburgh.

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Feb
12
to Feb 14

EACR “A Matter of Life or Death: Mechanisms, Models and Therapeutic Opportunities”, Bergamo, Italy

  • Centro Congressi Giovanni XXIII (map)
  • Google Calendar ICS

Evading programmed cell death is a major hallmark of cancer cells and contributes to tumour progression and therapy resistance. Emerging hallmarks such as metabolic plasticity, genomic instability and an immunosuppressive tumour environment allow the tumours to escape from standard cytotoxic as well as targeted therapies. Thus, understanding the underlying mechanisms in appropriate pre-clinical/clinical models is crucial for the design of more effective combination therapies to avoid treatment failure or tumour recurrence.

Building on the strong success of four previous editions, this will be the 5th conference on this topic. Its objective is to cover recent and exciting developments in the field of cancer research that are crucial to our understanding of the multifaceted role of cell death in tumour initiation, progression and therapy response.

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Feb
16
12:30 PM12:30

4th DNA Repair/Replication Structures & Cancer conference, Nassau, Bahamas

This conference will focus on structural and mechanistic insights into dynamic protein, chromatin, DNA and RNA complexes acting in DNA repair and its interface with DNA replication and transcription events relevant to cancer. This fundamental information will be pivotal for the accurate interpretation of cancer clinical data, design of clinical trials, prognosis, etiology and improving the currently 1/20 low success rate for oncology drug clinical trials. Informative talks and poster sessions along with vibrant discussions will foster productive interactions and collaborations.

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Mar
2
to Mar 4

Bridging between Basic Cancer Research and Innovative Therapies Rehovot, Israel

  • The David Lopatie Conference Centre, Weizmann Institute of Science (map)
  • Google Calendar ICS

The conference will address state-of-the-art basic and translational cancer research, focusing on recent discoveries in immunotherapy, genetic alterations, metabolism, microbiome, tumor microenvironment, senescence, cancer progression and metastases, and innovative technologies in cancer therapy. The program will include presentations by leading scientists and clinicians, and short talks selected from abstracts.

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Mar
15
to Mar 20

Keystone Higher-Order Chromatin Architecture in Time and Space, Whistler, BC, Canada

  • Whistler Conference Centre (map)
  • Google Calendar ICS


Mammalian genomes are folded in a hierarchy of compartments, topologically associating domains (TADs), subTADs, and looping interactions. As genome-wide chromatin architecture maps become widely available, the field is shifting focus from mapping to understanding the dynamics of such structures in development, the cell cycle, and on short time scales in single cells. A critical emerging goal will be to unravel the cause and effect relationship between genome folding and functions such as transcription, replication, recombination, and stability/maintenance. There is also a great need to evaluate the organizing principles governing chromatin topology across many biological conditions and genetic perturbations. Moreover, the role for 3D genome misfolding in the onset and progression of a wide range of human disease states remains an area of high interest across multiple disciplines and organ systems. The conference program will also include workshops on: (1) Leading computational methods to identify biologically relevant patterns in Hi-C data, (2) New genome mapping and imaging technologies, and (3) New data resources available through the 4D Nucleome consortium. Finally, we will conclude with a session devoted to novel tools for imaging and engineering the 3D genome. Overall, the 2020 Keystone meeting is meant to highlight new frontiers across disciplines in tackling the dynamics and functional roles of the 3D genome in cellular functions across time and space in development and disease.

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Mar
30
to Apr 1

Role of Epigenetics in DNA Damage Response, DNA Repair and Radiosensitivity, Cambridge, UK

Knowing how cells respond to DNA damage is critical to our understanding of tumourigenesis, genomic instability, and the cellular response to DNA-damaging chemotherapy and radiotherapy. DNA damage responses take place in the context of chromatin and in the midst of ongoing transcription and replication. Moreover, the metabolic environment, which is altered in tumour cells, influences these activities. In this conference, we aim to bring together researchers working on understanding DNA damage responses in the context of complex and dynamic cellular environments.

This is an exciting and fast moving area, and this conference features an excellent international line-up of speakers. The programme will address the challenges of understanding this complex field and will emphases new experimental approaches for interrogating these pathways. We will also consider how recent advances can be exploited in the clinic.

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Oct
5
to Oct 8

3rd Chromosomal Instability as a Driver of Human Disease conference, Lisbon, Portugal

This conference is a continuation of the DNA Replication as a Source of DNA Damage series.

The maintenance of genome integrity is critical for the suppression of several pathological disorders in humans, including cancer, infertility and neurodegeneration. Moreover, the accumulation of unrepaired errors in DNA is commonly cited as a likely cause of tissue and organismal ageing. Destabilization of the genome can occur as a result of several cell intrinsic or extrinsic factors, including errors arising during DNA replication or chromosome segregation, as well as exposure of cells to agents that induce DNA damage. In this conference, we aim to bring together scientists studying DNA replication, DNA repair and chromosome segregation with those interested in how chromosomal instability can influence human pathology. Moreover, we aim to show how high throughput and high content screening methods can be used as a discovery tool both for basic science applications and to identify potential therapeutic modalities.

Key Sessions

  • Pathways for repair of DNA damage and disrupted DNA replication forks

  • Screening tools for analysis of genome maintenance pathways and for development of new therapeutics

  • Chromosome fragility caused by difficult-to-replicate loci – sources and roles of DNA repair proteins

  • Chromosome instability as a driver of tumorigenesis, neurodegeneration and ageing

  • Exploitation of defects in chromosome maintenance in cancer treatment

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Jul
25
to Jul 26

5th International Conference on Oncology and Research, Rome, Italy

Oncology is a multi-disciplinary field, which is in need of many interdisciplinary methods to prognose, diagnose and treat cancer. Cancer, which is plaguing many low and middle Income Countries, is the second leading cause of death as per W.H.O. It is not a single disease to combat. There are more than 200 types of cancers, which need different treatments. It is alarming to know that deaths from cancer are also due to behavioural and dietary risks, such as: high body mass index; low fruit and vegetable intake; lack of physical activity; and use of tobacco and alcohol. Hence, there is a need for inter-disciplinary search globally. The conference provides a platform for cancer researchers, clinicians, oncologists, academicians and young scientists from all over the world to meet, share, update and comprehend the major problems encountered in oncology.

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Jul
4
to Jul 5

2nd Birmingham Symposium on Genome Structure and Function

  • University of Birmingham Medical School (map)
  • Google Calendar ICS

This two day research symposium on Genome Biology is organised by Birmingham Centre for Genome Biology (BCGB), which brings together researchers in the fields of Gene regulation, Epigenetics, DNA-repair, Genome stability, DNA-replication, Cancer Genetics and Computational/systems biology.

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Jul
3
1:00 PM13:00

Beatson International Cancer Conference , Glasgow, UK

For over 60 years, preserving genomic integrity has been considered the cornerstone of cancer prevention, with many mutated genes being identified as being drivers of tumour progression. However, as many mutated genes ultimately encode for dysfunctional proteins, it has become clear that the preservation of protein integrity and the control of protein production are also essential in preventing malignant disease.

Many pathways exist to maintain appropriate rates of protein synthesis and to preserve proteome integrity. Control at the point of translation and post-translational modifications is central to the increased anabolism of tumours, and errors in these processes can cause critical cellular stress responses. Equally, cellular protein turnover by ubiquitin-mediated mechanisms and autophagy are also critical for the tumour cell viability and dependence on these pathways in mitigating oxidative damage and metabolic stress has uncovered a number of cancer vulnerabilities.

Ultimately, it is the aim of this conference to detail and integrate the different ways in which protein dynamics both protect against cancer and contribute to cancer maintenance. As these pathways can also have perturbations and greater dependencies in cancer, it is also a key theme of our conference to better understand how these pathways can be targeted for cancer therapy.

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Jun
26
to Jun 28

British Yeast Group: Discovery to Impact, Newcastle, UK

Yeasts are very versatile, model unicellular eukaryotes that have been extensively used for over a century to explore fundamental aspects of living systems. Annual gatherings of the British yeast community have taken place since the 1980s and the Microbiology Society have been pleased to incorporate the last two meetings in its annual Focused Meeting programme.

BYG 2019 will explore the theme of Discovery to Impact in which fundamental research themes are integrated with applied themes, including biotechnological applications of yeasts, yeasts as disease models, and pathogenic yeasts. The programme features an exciting range of keynote talks from acclaimed invited speakers and will also give early career stage yeast researchers the opportunity to present their recent research results through a series of posters and offered oral presentations. The meeting will also feature a varied social programme offering delegates plenty of opportunities to make new connections, discuss research projects and to strengthen relationships in the British yeast community.

Key topics

  • Fundamental cellular processes, including metabolic cycles, chromatin biology, regulation of gene expression and control of quiescence

  • Yeasts as disease models

  • Pathogenic yeasts

  • Biotechnological applications of yeasts

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Jun
26
to Jun 27

Health Horizons 2019, Cambridge, UK

  • Cambridge Corn Exchange (map)
  • Google Calendar ICS

Health Horizons is a high caliber, two-day conference focusing on the future of the healthcare industry.

Over the previous 20 years we have seen a significant change in the healthcare industry. Small molecules have been pushed out of the blockbuster limelight by biologics. Decreasing sequencing cost has allowed more targeted R&D and the use of increasingly interdisciplinary data to influence prognosis has become standard practice. All of this points to a healthcare future with an increasingly personalized approach. But how will this future come together?

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Jun
23
to Jun 26

Ageing, Health and Rejuvenation, Rotterdam, The Netherlands

  • De Doelen International Congress Centre Rotterdam, The Netherlands (map)
  • Google Calendar ICS

The average age of the global population is increasing as a result of improved access to healthcare and changes in lifestyle. But, as life expectancy continues to increase, so too do the personal, socio-economic and financial burden of ageing-related diseases. Old age is the greatest risk factor for a number of chronic, progressive diseases, including diabetes, heart disease, cancer and neuro-degeneration. Over the past two decades, our understanding of the mechanisms of ageing at the molecular, cellular and organismal level has increased substantially. This improved knowledge now provides a realistic opportunity for us to intervene with the ageing process and to prevent or delay the onset of ageing-associated disorders through lifestyle modification and/or pharmacological and therapeutic interventions.

This conference brings together experts from diverse fields of research that explore the mechanisms of ageing and rejuvenation, from the perspective of genetics and epigenetics, cellular quality control and
senescence, stem cells, metabolism and brain function. The aim of the conference is to foster interactions and stimulate discussion of recent and unpublished advances in our understanding of the ageing process, and to explore new therapeutic opportunities for the rejuvenation and
preservation of organs and tissues to extend health span.

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Jun
17
to Jun 19

Australian Cell Cycle and DNA repair meeting, Sydney, Australia

The 2019 Meeting will be our biggest and best meeting ever, and we have already secured 4 outstanding plenary speakers:

Agata Smogorzewska (Genome Maintenance) – Rockefeller University, New York, USA

Agnel Sfeir (Telomere Biology) – Skirball Institute of Biomolecular Medicine, New York University, Langone Medical Center, USA

Gerry Hanna (Senior Clinical Oncologist) – Centre for Cancer Research and Cell Biology, Belfast, Ireland.

Karlene Cimprich (Genome stability and DNA replication) – School of Medicine, Stanford University, Stanford, CA, USA

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Jun
4
to Jun 7

Francois Jacob Conference: Evolution, structure and function of chromosomes high order structure, Paris, France

Considerable progress has been made in recent years in our understanding of the structure of chromosomes inside the nucleus or the bacteria, the role of long range contacts in gene regulation, the role of sub-chromosomal domains in controlling gene activation and single cell analysis. Similarly studies on the role of condensin and cohesins explain how long range contacts are stabilized and how chromosomes pair and segregate during cell division. However there is still an enormous gap in our understanding of the evolution of chromosomes structure, the physical processes that govern chromosome topology, chromosome condensation during mitosis, homology search during DNA repair or metaphase, the role of phase separation in the nucleus etc. We also do not fully understand how specific long range contacts are formed and resolved during the cell cycle, during differentiation or mitosis.

The time is ripe for the organisation of a dedicated scientific meeting to bring scientists investigating various aspects of chromosome biology, imaging, evolution, development and diseases together with physico-chemists and physicists interested in macromolecules and their assembly. We will also bring communities who do not mix frequently, those who study bacterial chromosomes, yeast and fungi with those who study invertebrates up to human and mouse cells and organisms.

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Jun
3
to Jun 6

2019 Cell Cycle Meeting, Trieste, Italy

  • Palazzo Congressi della Stazione Marittima di Trieste (map)
  • Google Calendar ICS

The 2019 Cell Cycle Meeting in Trieste, Italy, will highlight the 'diversity in cell cycle control mechanisms’, exploring cell cycle control in different organisms, focusing on the similarities and differences in fundamental properties, to elucidate the wiring of cell cycle control networks in health and disease. This meeting will be the first of a biannual European meeting to alternate with the well-established Salk Cell Cycle meetings in California, USA. By coordinating with the Salk Cell Cycle meetings and inviting a large number of speakers from outside Europe the Cell Cycle Meeting in Trieste will draw a truly global attendance from the international cell cycle community (see our program). This will provide a larger international community with an opportunity to merge and share ideas.

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May
20
to May 23

PARP 2019 "New avenues in basic and translational PARP research", Budapest, Hungary

  • Hungarian Academy of Sciences Research Centre for Natural Sciences (map)
  • Google Calendar ICS

PARP conferences are held since the 1970s, and the conferences were shuttled between Europe, USA and Japan. PARP2017 and PARP2019 aims to re-establish a series of bi-annual PARP conference series in Europe. PARP2019 follows the footsteps of the successful PARP2017 conference held in Budapest. The program of PARP2019 will cover the latest developments in basic PARP research, PARP-related pathophysiology and drug development.

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May
20
to May 22

Pint of Science Festival

Pint of Science brings scientists to discuss their latest research with you.

During May 20-22 2019, researchers across 24 countries will be sharing their discoveries with you in their local pub, bar or cafe.

Pint of Science is organised by a grass-root community of thousands of scientists across the world - come and meet us over a drink.

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May
20
to May 22

Structural and Molecular Biology of the DNA Damage Response, Madrid, Spain

  • Spanish National Cancer Research Centre (map)
  • Google Calendar ICS

Multiple pathways and macromolecular complexes maintain the integrity of our genome. When these control and repair mechanisms fail, damage to DNA accumulates and promotes the development of cancer and other diseases. This meeting brings together research leaders in the field with a focus on the structural basis and molecular mechanisms.

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May
20
to May 21

"Mechanisms and Consequences of Chromosomal Translocations in Cancer" Meeting, Paris, France

The topic of the meeting “Mechanisms and Consequences of Chromosomal Translocations” covers the basic and translational underlying of chromosomal translocations in cancers. The aim of this meeting is to share the latest findings on chromosomal translocations, with major implications in our understanding of cancer etiology, onset, evolution and therapy resistance.

The meeting will be organized in three sessions:

  1. Origins and mechanisms of chromosomal translocation formation

  2. Toward a faithful modelling of chromosomal translocations

  3. Diseases, functional consequences and treatment perspectives

Time will be dedicated to discussions with the aim to foster new ideas and collaborative projects. Finally, we will provide opportunities for oral and poster presentations for young scientists.

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May
1
to May 4

18th International Ataxia-Telangiectasia Workshop (ATW2019), Houston, Texas, USA

  • Houston Methodist Research Institute (map)
  • Google Calendar ICS

The 18th International Ataxia-Telangiectasia Workshop (ATW2019) will bring together clinical and research scientists to explore the latest advances in understanding A-T and its treatments as well as the
underlying function of ATM in cancer, aging and other neurological diseases.

The scientific program features these six sessions:

* ATM and ATM-related Response Pathways
* ATM and Neurodegenerative Diseases
* ATM and Clinical Investigation of Human Diseases
* Chromatin Regulation in Genome Maintenance
* Canonical and Non-canonical Signaling and Repair Processes
* Mechanisms of DNA Damage Repair

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May
1
to May 4

EMBO Workshop Chromatin and Epigenetics, Heidelberg, Germany

Epigenetics refers to heritable change in gene expression that does not involve changes to the underlying DNA sequence. At least three systems including DNA methylation, histone modifications and non-coding RNAs (ncRNA) are considered to play fundamental roles in epigenetic regulation. Research over the last two decades has uncovered the role of epigenetics in a variety of human disorders and fatal diseases. Moreover influence of age, environment, lifestyle, and disease state on epigenetic states is being increasingly appreciated and actively studied.

This conference provides an international forum for cutting edge research in chromatin and epigenetics. It provides the "focal hub” for people to present their research and exchange ideas in a European venue. Renowned speakers will cover the latest advances in the field, including chromatin regulation, chromatin dynamics, signalling to chromatin, nuclear architecture and dynamics, developmental epigenetics, epigenomics, epigenetics and human diseases, genome stability, environmental epigenetics, and transgenerational inheritance.

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Apr
30
to May 4

Telomeres and Telomerase, Cold Spring Harbor, NY, USA

  • Cold Spring Harbor Laboratories (map)
  • Google Calendar ICS

We are pleased to offer the eleventh Cold Spring Harbor meeting on Telomeres & Telomerase to bring together a diverse group of scientists studying various molecular, cellular and genetic aspects of telomeres and telomerase biology.

Topics:

  • Regulation of Telomerase Expression & Activity

  • Telomerase Biogenesis & Structure

  • Telomere Replication

  • Mechanisms of ALT

  • Mechanisms of Telomere Protection

  • Telomere Protein Functions at Telomeres and Genomewide

  • Telomere Shortening & Mechanisms of Senescence

  • Telomeres & Human Health & Disease

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Apr
8
to Apr 11

33rd Genes and Cancer Meeting, Cambridge, UK

‘Genes and Cancer’ is a broad-based research meeting focusing on basic and translational cancer research. The meeting is one of the UK and Europe’s best cancer research meetings and the meeting is now in its 33rd year. This year’s event is focused on four main research themes.

‘Gene Regulation in Cancer’

‘Ubiquitin Signalling and Inflammation’

‘Tumour Metabolism’

‘Model Organisms in Cancer Research’.

In addition to these 4 themes there will be a Keynote lecture and short talks will be chosen from submitted abstracts (including short talks for junior principal investigators and short talks for post-docs/students). A poster session also forms part of the programme which runs concurrently with a trade exhibition. A number of prizes are awarded for the best posters. The main aim of the meeting is to bring together young scientists with some of the world’s leaders in cancer research in an informal environment that maximizes interaction between speakers and delegates. It is hoped that the format and atmosphere at the conference will serve as an inspiration to those at the early stages of their scientific careers.

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Apr
7
to Apr 11

EMBO Workshop "Genome Dynamics in the Neurosciences and Aging", Israel

Genome stability, which is essential for cellular homeostasis, relies primarily on the DNA damage response network. Genome stability is also essential to the proper functioning of the nervous system, evidenced by the prominence of neurodegeneration in many genome instability syndromes. Recent evidence suggests a broader role of genome stability in human health, one that affects aging and common chronic morbidities. Genome Dynamics in Neuroscience and Aging (GDNA) is an interdisciplinary EMBO workshop bringing together researchers of the DNA damage response, neuroscience, aging, cell senescence, mitochondrial function, and metabolism to discuss the links between genome stability and these aspects of human physiology, and the impact of genome instability on them and on longevity.

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Apr
2
to Apr 3

2019 Research and Innovation ELRIG Conference, Cambridge, UK

The overall meeting focus for 2019 will be "innovations for the future of drug discovery" comprising the following four main sessions:

  1. Innovating the future of rationale drug design

  2. Where are new drug target hypotheses coming from?

  3. Therapeutic approaches of the future

  4. Next generation in vitro models for drug efficiency & safety

This meeting is organised by ELRIG, European Laboratory Research and Innovation Group

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Mar
19
1:00 PM13:00

London Cell Cycle Club Meeting, London, UK

The London Cell Cycle Club provides a venue for labs doing fundamental cell cycle research in model organisms to interact with those using mammalian cells to drive research in a more ‘translational’ direction.

In addition, the meeting provides a forum of expertise in cell cycle biology to critique new work, enabling new ideas to be ‘distilled’ prior to publication.

Our aims

  • Encourage discussion in a relaxed atmosphere

  • Provide an opportunity for students and post-docs to present new and unpublished data

  • Inspire new collaborations within the UK and European cell cycle field

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Mar
7
to Mar 8

Medicine at the Crick "Biotherapies in cancer: towards improving clinical outcomes", The Francis Crick Institute, London

  • The Francis Crick Institute, London (map)
  • Google Calendar ICS

Our new Medicine at the Crick event series showcases major advances in biomedical science and raises awareness of the medical implications of major scientific advances amongst the Crick and wider UK biomedical community. Each event comprises a series of short talks, one or two keynote lectures and a panel discussion.

Our third event in the series, Biotherapies in cancer: towards improving clinical outcomes, will review the profound opportunities of CAR-T cell therapy, adoptive cellular immunotherapies and checkpoint inhibitor therapy in the management of haematologic and metastatic solid tumours. These Immunotherapies, by leveraging the patient's immune system, are transforming clinical care, resulting in prolonged survival and even cancer cures in a previously palliative setting. The event will review recent breakthroughs in the field, challenges and opportunities in the translation of scientific findings into the clinic and the promise of leveraging adaptive cellular therapies to tackle cancer clonal evolution for patient benefit.

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Mar
7
to Mar 8

Cancer Research UK Cambridge Institute International Symposium 2019, Cambridge, UK

  • Cancer Research UK Cambridge Institute (map)
  • Google Calendar ICS

Radical approaches to cancer prevention

Each year we welcome experts from across world and, as in previous years, we expect the meeting to fill up fast so book early to avoid disappointment!

We’ll be covering a wide range of topics including:

  • Using new technology to reduce and prevent disease.

  • Training the immune system.

  • Preventing cancer through medical intervention.

  • Preventing cancer through lifestyle and policy.

See the scientific programme for the full list of speakers, include keynote talks from Nobel laureate Prof Harald zur Hausen, Prof Mette Kalager and Dr Christopher P Wild.

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Feb
27
to Feb 28

CRISPR in Drug Discovery 2019: From Targets to Therapeutics, Oxford, UK

Genome Engineering, including Zinc-finger, TALEN and most recently CRISPR/Cas9, has become a powerful tool in the drug discovery pipeline. This meeting will focus on the application of genome engineering to identify novel drug targets through large scale CRISPR based functional genomics studies, target validation in developing advanced cellular and in vivo disease models, and the pioneering applications in therapeutic genome editing. A current perspective of the applications of these rapidly developing technologies with a focus on drug discovery applications will be the meeting’s focus.

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Feb
27
to Mar 1

AEK Cancer Congress "Translating Cancer Biology: From Basic Mechanisms to Therapeutic Exploitation", Heidelberg, Germany

  • EMBL Advanced Training Centre (map)
  • Google Calendar ICS

The AEK Cancer Congress is a medium size conference with around 500 participants. It is funded by the German Cancer Society (this time with additional support of the German Research Foundation) and will be held in 2019 under the theme “Translating Cancer Biology: From Basic Mechanism to Therapeutic Exploitation”.

The conference comprises eight sessions on seven key topics of cancer biology: Cancer Immunology & Immunotherapy, Targeting Myc and Ras, Replicative Stress and DNA Damage Response, Cellular Senescence in Cancer, Metastasis, Novel Tools and Model Systems in Cancer Research and Tumor Microenvironment.

Besides 21 talks given by internationally renowned leaders in these fields, a total of 16 abstract talks to be selected will give students, postdocs and junior faculty the chance to present their latest research. In addition, the best posters will be presented as “Flash Talks”.

We particularly would like to encourage students and postdocs to attend the conference and offer special registration rates for them. In addition, there will be travel bursaries for young investigators.

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Feb
23
to Feb 26

3rd Exploring DNA Repair Pathways as Targets for Cancer Therapy Conference, Nassau, Bahamas

Defect in DNA damage repair and checkpoint control is the underlying mechanism for tumorigenesis, since it allows the accumulation of multiple genetic alternations, which are essential for the initiation of tumorigenesis. This has been clearly illustrated to be the cause of several human cancer-prone syndromes and also revealed by recent human genome studies. On the other hand, defective DNA repair and checkpoint activation also make cancer cells more vulnerable for particular DNA damaging agents or inhibitors that specifically disrupt some of these checkpoint pathways. With the increasing understanding of defects in DNA repair and checkpoint control in tumorigenesis, there are extensive interests in exploring these deficiencies, especially taking advantage of the synthetic lethality concept and targeting particular DNA repair and checkpoint pathways for cancer therapy. The purpose of this conference is to bring together basic, translational and clinical investigators and discuss the current and future directions, opportunities and obstacles in the development of these anti-cancer modalities and how to best apply these concepts in clinical practice.

  • Key Sessions
  • Highlight recent advances in the field of DNA damage repair
  • Identify novel targets in DNA repair and checkpoint pathways
  • Explore the concept of synthetic lethality for cancer treatment
  • Assess the therapeutic potential of new anti-cancer modalities
  • Learn mechanisms of therapeutic resistance and ways to improve cancer therapy
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Feb
13
to Feb 16

6th Nucleic Acids Conference, Nassau, Bahamas

This meeting is a continuation of the Zing Conferences Nucleic Acids series.

The key role of nucleic acids is to encode and process genetic information at a molecular level. DNA is the genetic library of the cell, while RNA transports, translates and controls the expression of that information. DNA must be copied with unprecedented accuracy once every cell cycle. It is under constant endogenous and environmental onslaught, and a variety of repair pathways are necessary to maintain the integrity of the genetic blueprint. DNA is the only cellular molecule for which repair occurs to a significant extent. DNA undergoes recombination, a kind of molecular cut and re-join that creates diversity to facilitate evolution, as well as providing an important repair pathway. In eukaryotes something like 2m DNA is packaged into chromosomes so that it packs into the cell nucleus with a diameter of just 6 µm, while remaining accessible to the cellular machinery that reads out its genetic information. 

RNA is the dynamic worker bee of genetics to the DNA's queen, and an extremely versatile molecule. In the central dogma RNA is the messenger (mRNA) and translators (tRNA) that passes the information between the DNA genome and the protein synthesis machinery, yet it does much, much more. In translation of the genetic information it forms the architectural framework and catalytic center of the ribosome. In eukaryotic cells the pre-mRNA must be processed by the precise removal of intervening sequences (introns), carried out by a large and dynamic RNA-protein machine called the spliceosome. Increasingly we realize that RNA is also involved in critical and complex regulatory processes. RNA can act as a molecular switch responding to small molecules in order to control gene expression. Indeed while most of the genomic DNA does not encode proteins, almost all of it is transcribed into RNA. We are only just beginning the long journey of understanding what all this non-coding RNA is doing - it is very much the 'dark matter' of biology ! Lastly RNA can also accelerate chemical reactions by a million fold or more in the manner of an enzyme. This is very likely of key significance in the origin of life on the planet more than three billion years ago.

Understanding processes involving DNA and RNA at the molecular and chemical level is the central theme of this conference, with a marked structural and mechanistic perspective. The meeting will provide a platform for researchers to discover and discuss the latest advances in the field of nucleic acids, DNA and RNA, with exciting opportunities to share and receive feedback on unpublished data.

Discussion topics will include;

  • DNA replication
  • DNA repair
  • DNA recombination
  • RNA structure and function
  • Translation and the ribosome
  • Silencing
  • CRISPR/Cas and genome editing
  • Gene regulation and riboswitches
  • RNA catalysis
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Feb
10
to Feb 15

Gordon Research Conference, "Genome Maintenance: Mechanisms of Repair, Consequences of Failure for Human Disease and Opportunities for Therapeutic Intervention", Ventura, California, USA

Our genome is constantly challenged by environmental and endogenous sources of DNA damage and replication stress. A multitude of DNA repair and DNA damage response mechanisms successfully operate to maintain genome stability. However, failures do happen resulting in diseases ranging from rare developmental and premature aging syndromes to common cancers. This Mammalian DNA Repair GRC and associated GRS will bring together diverse researchers studying the mechanisms that maintain genome stability and the consequences for human health when these mechanisms fail. In addition, the conference will explore opportunities that DNA repair and signaling networks provide for therapeutic intervention, and discuss how we can harness these DNA metabolism pathways for genome editing.

A diverse cadre of invited speakers will present new discoveries, approaches, and concepts at the frontier of mammalian DNA repair. Additionally, multiple speakers will be selected from abstract submissions and vigorous poster sessions will provide opportunities for sharing participant’s latest research. This GRC will continue a strong tradition of welcoming young scientists, connecting new and senior members of the field, and engaging all participants in discussion through an open atmosphere of scientific exchange.

Applications from investigators interested in all aspects of DNA metabolism and genome stability from basic mechanisms to clinical intervention are encouraged. Trainees are encouraged to attend this GRC and the associated GRS.

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Feb
9
to Feb 10

Gordon Research Seminar, "Genome Maintenance: Mechanisms of Repair, Consequences of Failure for Human Disease and Opportunities for Therapeutic Intervention", Ventura, California, USA

The Gordon Research Seminar (GRS) on Mammalian DNA repair is a unique forum for graduate students and post-doctoral researchers, representing a broad range of expertise and interests, to present and exchange new data and leading-edge ideas. The meeting will take place in a relaxed and highly engaging environment aimed to empower young scientists to communicate ideas among their peers, and will also include opportunities to network and interact with invited experts and senior scientists from various career paths and stages of professional development.

This Mammalian DNA Repair GRS will bring together early career scientists studying the cellular DNA signalling and repair mechanisms that maintain genome stability. Our genome is constantly being damaged from external and internal sources. To combat this, and to prevent genome instability, cells have evolved a multitude of efficient DNA repair pathways that detect, signal and repair DNA damage. The importance of these DNA repair pathways is highlighted by the existence of numerous human diseases that are associated with mutations in DNA repair factors. This meeting will encourage stimulating discussions on unpublished research and recent developments in the field of mammalian DNA repair, particularly highlighting new successes new opportunities, and also discussing the consequences associated with a failure to respond and/or repair DNA damage.

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