The Steve Jackson Laboratory Website
Transformative discoveries in genome and cellular integrity

Conferences

Sep
25
to Sep 27

3rd International Cancer Symposium

  • Convention Centre of Lyon (map)
  • Google Calendar ICS

The meeting aims to gather scientists and clinicians interested in cancer biology and its therapeutic innovations, and to present the latest scientific advances in these fields.
Through the participation of internationally renowned scientists, the Symposium aims to address crucial questions about the fundamental issues of cancer biology with a special emphasis on interactions between basic, clinical and translational research.

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Sep
26
to Sep 27

Genomic Medicine 2017

The scientific theme for this meeting like most Biotexcel meetings will cover the areas where Next Generation Sequencing is used in the analysis of human disease.  These topics will include different disease areas where particularly promising genomic studies have been performed; large population studies such as the East London Genes & health project; whole genome & whole exome studies; epigenomics and many other topics.  In this meeting we will also hear from commercial genomic companies, whether those that currently have genomic solutions on the market, or those that are spin-outs or in the research or earlier phases, as well as hearing from Illumina’s Chief Scientist David Bentley.

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Sep
27
to Sep 30

IARC 2017

  • Palazzo dei Congressi (map)
  • Google Calendar ICS

The 2nd International Ataxia Research Conference will be held on September 27-30, 2017 in Pisa, Italy. The focus of the meeting is a comprehensive scientific review of new research from disease definition to therapeutic treatments. The conference will include Friedreich’s ataxia and other recessive ataxias (eg: ataxia with oculomotor apraxia), dominant ataxias (eg: spinocerebellar ataxias, DRPLA, episodic ataxias) and autoimmune ataxias.

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Oct
2
to Oct 6

4th EMBO Conference: DNA Damage Responses in Cell Physiology and Disease

The DNA damage response (DDR) is a complex signaling network including cell cycle checkpoints, DNA repair and DNA-damage tolerance pathways. The DDR is affected by, and impacts on, many cellular components and processes, including chromatin structure, DNA replication, transcription and cell cycle progression. Failure to properly respond to DNA damage leads to genomic instability, an underlining cause of various human syndromes and also associated with many age-related diseases, particularly cancer. Notably, it is becoming clear that the DDR is an attractive therapeutic target for cancer and other disease areas. This EMBO Conference will cover all the above topics in ways that will link detailed molecular mechanisms of the DDR and associated processes to human ageing, disease and therapeutic applications.

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Oct
4
to Oct 8

Nuclear structure and dynamics

  • L'Isle sur la Sorgue France (map)
  • Google Calendar ICS

This EMBO Conference will cover chromosome structure and organization, epigenetic modifications, chromatin remodelling and reprogramming, silent chromatin, genome stability and telomere biology, replication and repair, nuclear RNA, systems biology of genome functions and nuclear compartments.

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Oct
8
to Oct 11

2nd Meeting on the Molecular Biology of Ageing

  • Groningen The Netherlands (map)
  • Google Calendar ICS

We have succeeded to gather world-leading scientists working in the diverse research areas that are relevant for understanding the biology of ageing. The meeting will begin on October 8th with an Opening Lecture by Professor Andrew Dillon,  Thomas and Stacey Siebel Distinguished Chair in Stem Cell Research at the Department of Molecular and Cell Biology at Berkeley.

The programme of the Meeting is organized into 10 sessions covering a wide range of topics related with the process of ageing.

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Oct
17
to Oct 18

The CRISPR FORUM: CRISPR gene editing - Drug discovery tool or therapeutic revolution?

The discovery of the RNA programmable nucleases Cas9 and Cpf1 has greatly facilitated genome editing. The impact of CRISPR technology has been universal, bringing drug discovery to an era of whole genome knockout screens and widely distributed multiplexed in vivo gene editing experiments, as well as moving into the clinic to join ZFN and TALEN powered therapies progressing towards registration.

This unique meeting, being held in Dublin, will bring leaders in the field of gene editing together with a wide academic and commercial audience, to explore the new horizons in drug development and therapeutics brought by advancements in CRISPR technology.

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Oct
23
9:30am 9:30am

Cambridge International Rare DIsease Summit

This year’s Summit revolves around “Re-imagining the Patient Journey”, seeking to create a forum that brings together all rare disease stakeholders in a spirit of collaboration, innovation and passion to re-imagine and re-invent the rare disease patient journey.

We have listened closely to the excellent feedback from delegates in 2016 to bring more powerful patient stories, tracing the journey from early symptoms through their odyssey to diagnosis and their successful patient group, clinician and pharma collaborations leading to clinical trials and hope for future treatment pathways.

Anchored by powerful patient voices, this one-day conference will explore:

  • Rare disease patient journeys from symptoms through to treatment
  • Empowering the patient revolution
  • Data mining and management
  • Pharma 'adopting' a rare disease
  • Drug re-purposing and matching
  • Gene therapy
  • Local rare disease research and projects
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Oct
29
to Nov 1

Protecting the code - Epigenetic impacts on genome stability

The maintenance of genome stability takes place in a chromatin environment, and it is increasingly evident that epigenetic regulation is a key component of genome stability. Notably, epigenetic pathways are frequently perturbed in cancer cells. Understanding the interplay between epigenetic regulation and genome stability at a molecular level is critical to cancer biology and has important translational implications. 

The programme will address the challenges of understanding this complex field and will emphasise new experimental systems for interrogating these pathways. While the emphasis is on understanding molecular mechanisms of epigenetic impacts on genome stability, we will also consider how recent advances can be exploited in the clinic. 

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Nov
10
2:00pm 2:00pm

London Chromatin Meeting

Come and participate in this free half day meeting, present your research and hear about the latest developments in the field of chromatin biology.      

The London Chromatin Meeting is a series of meetings which provide a forum for scientists (especially students and young postdocs) to present their work and for attendees to network in a relaxed and friendly environmen.

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Nov
15
5:00pm 5:00pm

Workshop: "Chromosomal Instability: From Molecular Mechanisms to Disease"

Current Trends in Biomedicine 2017 workshop on "Chromosomal Instability: From Molecular Mechanisms to Disease"

Organizers:
Pablo Huertas (Andalusian Molecular Biology and Regenerative Medicine Centre (CABIMER), Sevilla, Spain)
Andres J. López-Contreras (Center for Chromosome Stability (CCS), University of Copenhagen, Copenhagen, Denmark)
Guillermo de Cárcer (Spanish National Cancer Centre (CNIO), Madrid, Spain)

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Jan
28
to Feb 2

Ubiquitin Signaling

Scientific Organizers: David Komander and Sylvie Urbé

These are exciting times for ubiquitin research: potential targets for small molecule inhibitors are emerging in a variety of human diseases and being exploited by the pharmaceutical industry. At the same time new enzymes regulating ubiquitin modifications are still being discovered, and the complexity of ubiquitin modifications continues to increase with the emerging cross-talk between post-translational modifications. This meeting will focus on the latest insights in the large area of cellular regulation mediated by ubiquitin and ubiquitin-like modifiers. Key goals are to provide overviews and updates on emerging frontiers, inform on new developments to understand the complexity, and encourage efforts to exploit the system to provide new treatments for human diseases. Rather than being organized around key enzymes in the cascade, sessions will focus on biological areas, ensuring a balanced mix of mechanistic and physiology aspects. The meeting will feature both key opinion-leaders on ubiquitination who are known to present unpublished results and leading researchers from peripheral fields who will contribute new ideas. A short selection of company-associated academic speakers will provide insights into the translational opportunities in this area.

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Feb
1
to Feb 3

4th EACR Conference A Matter of Life or Death: From Basic Cell Death Mechanisms to Novel Cancer Treatments

Evading cell death is a hallmark of cancer cells, which contributes to tumour growth and therapeutic resistance. But cancer cells also highjack mechanisms like protective autophagy or senescence to promote tumour growth. Cell death is an important determinant of the immune response to cancer, which may either increase the antitumour effect or promote tumour growth. The conference will cover exciting new insights into this highly-relevant field

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Feb
5
to Feb 7

Toulouse OncoWeek 2018

This symposium is a large and important event that gather scientists and clinicians and aims at presenting an overview of new concepts and studies in the field of oncology.
The program for 2018 will include 6 sessions (Metastasis and microenvironment, Genetic instability and DNA damage, Epigenetics and Non coding genome, Cancer immunotherapy, New therapeutic strategies and Clinical Research).

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Feb
11
to Feb 15

3rd DNA Replication/Repair Structures and Cancer Conference

  • Fiesta Americana Condesa (map)
  • Google Calendar ICS

The remarkable stability of the human genome is lost in cancer cells due to the loss of efficient and accurate repair in the context of oncogene-induced replication stress and elevated transcription. DNA replication is furthermore emerging as a surprisingly fragile and complex process requiring fork protection and restart, R-loop resolution, and repair. Unresolved replication and repair intermediates signal apoptosis. The synthetic lethality and essentiality resulting from replication-repair stresses thus suggest repair inhibitors as tools to control pathway selection and damage outcomes and to design advanced therapeutics. The 2018 DNA Replication and Repair Structures & Cancer conference will focus on structural and mechanistic insights into dynamic protein, DNA and RNA complexes acting in DNA replication and repair events relevant to cancer.

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Mar
5
to Mar 8

Genomic Instability and Gene Therapeutics in Neurological Diseases

With the rapidly emerging new tools including genomics, bioinformatics, metabolomics and proteomic analysis and new powerful editing tools such as CRISPR/CAS9 we are getting closer to more defined understanding of the complex cellular pathways underpinning neurodegeneration, which underlie many debilitating pathological and age-associated neurological demise. This is a great opportunity to assemble a rich programme of international speakers to address the latest advances from basic research to clinical applications in disorders of the central nervous system.

The conference will primarily focus on amyotrophic lateral sclerosis/frontotemporal dementia (ALS/FTD), spinal muscular atrophy (SMA), Alzheimer’s disease/dementia, and repeat expansion disorders with translational spin focussing on recent advances in gene based-therapeutics.

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Mar
23
to Mar 27

Chromatin Architecture and Chromosome Organization

  • Whistler Conference Center (map)
  • Google Calendar ICS

Understanding the principles governing genome regulation is one of the major challenges now facing biomedical research in the 21st century. Deciphering structure-activity relationships of the genome and its partners in the context of the cell nucleus is a necessary step for understanding the basis of development and disease, as well as for the elaboration of strategies against particular forms of cancers and genetic disorders. The genome is not a linear molecule of DNA randomly distributed in the nucleus, but exists as a three-dimensional (3D) object, intricately folded and packaged, structured around nuclear bodies and landmarks, acted upon by countless force-generating nano-machines and remodeling factors. With the recent advances that have been made in microscopy, biochemistry and modeling, the time is ripe to fully address the study of the genome in 3D space and time and consider it as a complex, dynamic biological system. Up until recently, many of the scientists involved in chromatin biology and epigenetics would attend meetings dedicated to this topic and would not necessarily interface with scientists using advanced imaging or physical and mathematical modeling approaches. This meeting will bring together some of the world’s leading experts and emerging talents at the interface of these topics to explore chromosome architecture and its dynamic relationship with genome function. Specifically, it will explore: 1) Chromatin structure and how this relates to gene expression and genome functions such as DNA replication and repair; 2) Chromosome conformation and the new insights into genome organization that have emerged using new technologies; 3) The nature of the chromatin partners (proteins, RNAs) that underlie chromatin folding and functions and their dynamic relationships in different contexts (cell cycle, development, environmentally induced changes, etc.); 4) Emerging imaging technologies and microscopy and the answers they are bringing to the dynamics of chromatin and chromosome architecture; and 5) New physical and mathematical modeling approaches to further our understanding of the principles governing chromatin architecture.

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Mar
25
to Mar 30

DNA Damage, Mutation and Cancer

The 2018 Gordon Research Conference on DNA Damage, Mutation and Cancer is developed around the theme of exploiting fundamental knowledge to advance treatment and prevention. Rich and ever-increasing information is available on the specific mutations that are the molecular basis of cancer. Many mutations can be traced to specific types of damage to the DNA, while others arise from DNA replication errors or unknown causes. Technologies are being refined to determine the origins of these mutations, and monitor the accuracy and reproducibility of cancer genomic data. Biological and structural analyses can assess which mutations are functionally relevant. Specific mutations can confer vulnerabilities, making individual cancers more responsive to treatment with DNA damaging agents.

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May
6
to May 11

Precision Medicine in Cancer

Thanks to next-generation sequencing, we have started to unravel the cancer genomic landscape of several major cancer entities that contributes to the pathogenesis and/or evolution of the disease. For the majority of cancer subtypes, a quite diverse and complex mutation pattern is observed, with a limited number of frequently mutated genes accompanied by a long tail of genes with low-frequency mutations. Some of these genes have already been implied to have diagnostic, prognostic/predictive and even therapeutic impact, while most mutations still require functional validation. In parallel, large efforts have been made to design novel strategies targeting key cellular pathways and processes, which in turn has led to introduction of targeted therapy in selected entities. However, there is still a gap-of-knowledge and urgent medical need how to combine the genetic information with risk-stratification and treatment algorithms in the individual patient, i.e., precision medicine. This symposium will exemplify large sequencing efforts carried out in different cancer types, including both solid tumors and hematological malignancies, which paved the way for the incorporation of next-generation sequencing-based approaches into clinical routine diagnostics and every-day patient care. The conference will encompass the rapidly evolving field of disease monitoring by ultra-sensitive sequencing of tumor-specific mutations, as well as introduce novel approaches and other omics technologies and functional studies that will aid future efforts in precision medicine. Finally, successful examples of how genomic findings have spurred development of targeted therapies will be presented. In summary, the symposium will bring together basic scientists, translational researchers and clinicians to meet and discuss a consorted action towards precision medicine in cancer.

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Jun
30
to Jul 3

25th EACR Biennial Congress

The theme of the Congress is ‘From Fundamental Insight to Rational Cancer Treatment’, covering the journey of discovery and development ‘from bench to bedside’. The Congress will feature world-class speakers discussing the most innovative current research topics, including a special education track aimed at clinicians. As well as high-profile plenary sessions, the programme offers parallel symposia, allowing participants to build their own scientific programme according to their interests.

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Jul
27
2:00pm 2:00pm

Chromatin Structure and Function

The Chromatin Structure and Function GRC is one of the longest standing conferences on chromatin, dating back to the 1970s. The meeting covers timely and important topics, including: X-ray crystallization and biophysical studies of individual nucleosomes and higher order structures, the identification and functions of histone post-translational modifications, the regulation and structure of histone modifying enzymes, the components and mechanisms of action of ATP-dependent chromatin remodeling assemblies, replication-dependent and replication-independent mechanisms of chromatin assembly, nucleosome positioning and phasing, the functions of histone variants, gene silencing in heterochromatin, chromatin remodeling during gene activation and repression in euchromatin, chromatin remodeling during DNA repair and recombination, the importance of heterochromatin organization at centromeres and telomeres to the maintenance of genome integrity. The role of chromatin remodeling factors and histone modifications to large scale organization of chromosomes and the location of loci within the nucleus are also discussed, as is the role of chromatin modifications and DNA methylation in epigenetics, particularly with regards as to how mutations in chromatin remodeling and histone modifying activities affect developmental processes and contribute to human disease.

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Jul
29
to Aug 3

DNA Topoisomerases in Biology and Medicine

The helical nature of the double helix causes a topological problem for its replication. Watson and Crick were well aware of this potential problem, and in 1953 they stated: "Since the two chains in our model are intertwined, it is essential for them to untwist if they are to separate... Although it is difficult at the moment to see how these processes occur without everything getting tangled, we do not feel that this objection will be insuperable." We now know that this problem is solved by the DNA topoisomerases, which were first reported in 1971 by James Wang, with the discovery of bacterial topoisomerase I. Over the past ~40 years these enzymes have been found in all organisms (prokaryotes, eukaryotes, viruses and archaea) and to perform roles that are vital for survival, supporting replication, transcription and other processes where topological problems in DNA need to be resolved. The enzymes are ‘marvelous molecular machines’ catalyzing the seemingly magical task of passing one piece of DNA through another to catalyze changes in DNA topology. Some of the enzymes are molecular motors having the ability to transduce the free energy of ATP hydrolysis into torsional stress in DNA (supercoiling). Although the outline of their mechanisms has been established, a great deal is unknown and emerging technologies, such as single-molecule methods, need to be applied to gain a deeper understanding of these enzymes and their roles in cellular processes. Topoisomerases have also become key drug targets both for anti-bacterial and anti-cancer chemotherapy. This is due to their essential nature and because of their mechanism of action, which involves transient DNA cleavage that, if disrupted, can lead to highly cytotoxic events. Study of these enzymes in the context of myriad cellular processes is of key importance in research leading to the development of new chemotherapeutic agents.

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Sep
24
to Sep 26

1st Crick International Cancer Conference

  • The Francis Crick Institute (map)
  • Google Calendar ICS

The 1st Crick International Cancer Conference will bring together leading cancer scientists from all over the world to discuss the latest findings in cancer metabolism, the tumour microenvironment, and how the cancer genotype changes over time. In addition to a line-up of world leading speakers, there will be many opportunities for early stage researchers to present short talks and posters.

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Sep
15
to Sep 19

Ubiquitin and SUMO: From molecular mechanisms to system-wide responses

Post-translational modification of proteins with ubiquitin and ubiquitin related modifiers such as SUMO is one of the most commonly used regulatory mechanisms in cells. The purpose of this conference is to accelerate education and understanding of ubiquitin, SUMO and other Ubls at molecular, cellular and organismal levels and thus facilitate discovery as well as medical or biotechnological translation.

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Sep
6
to Sep 8

Histone variants: Molecular functions in health and disease

  • BioMedical Center (BMC) Ludwig-Maximilians University (LMU) (map)
  • Google Calendar ICS

This EMBO Workshop features histone variants, which are part of an interconnected "epigenetic" network including DNA methylation, posttranslational histone modifications, chromatin remodeling, regulatory RNAs and nuclear organization. Worldwide research on histone variants over the last years has revealed their important function in gene regulation, cell cycle progression, DNA damage repair, genome stability, cell differentiation and organism development. Additionally, recent studies have highlighted the role of mutations or deregulation of expression of histone variants and their binding partners in diverse diseases, most notably cancer.

This EMBO Workshop will provide a comprehensive representation of all of these histone variant-related processes, with a balanced portrayal of different model organisms, including rare variants in parasites and evolutionary aspects, as well as presentations of the different variant families, such as linker histone variants. Specialists of variant deposition mechanisms, chromatin structure and interaction networks, will meet with biochemists focusing on chemical modifications, as well as developmental biologists, bioinformaticians and physiologists to share common interest in histone variants in parasites, yeast, insects, plants and mammals.

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Sep
5
to Sep 9

Eukaryotic DNA Replication & Genome Maintenance

  • Cold Spring Harbor Laboratory (map)
  • Google Calendar ICS

Topics:

Replication initiation factors and origins
Replication timing, chromatin, and development
Replisomes and replication fork progression
Replication fork stalling and replication stress
Coordination of replication with cell cycle and transcription
Response to DNA damage
Genome instability & mutagenesis
Telomeres, diseases and cancer

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Jul
23
to Jul 28

Helicases and nucleic acid-based machines: Structure, mechanism and regulation and roles in human disease

  • Kloster Banz Conference Centre (map)
  • Google Calendar ICS

Helicases and nucleic-acid based machines are involved in all aspects of nucleic acid metabolism. Their malfunction is frequently associated with human disease.

In the past, research on helicases mainly focused on the mechanism of individual enzymes. Recent developments such as the identification of target sites and interaction partners on a genome-wide level, and advances in structural biology and single molecule imaging in vitro and in vivo with increasing resolution, now increasingly allow to understand the regulation of helicase function within large complexes and regulatory networks in their natural environment.

Since 1999 this biannual meeting has developed our understanding of helicases and nucleic acid-based machines. This year’s meeting puts a strong focus on new emerging topics, including recent technological developments, new genome wide screening approaches, molecular interactions and single molecule techniques.

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Jul
3
to Jul 6

2nd DNA Replication as a Source of DNA Damage Conference

The maintenance of genome integrity is critical for the suppression of cancer and premature ageing. Only recently has it become appreciated that DNA replication stress is a crucial driver of genomic instability. The timely progression of replisomes can be disrupted by lesions and secondary structures in the template, by bound proteins and by conflicts with the transcription machinery. A prolonged pause of the replisome then exposes single stranded DNA, which, due to its recombinogenic nature, can lead to genome rearrangements, fragile site expression and cell death. Importantly, some cancers present excessive endogenous levels of replication stress, which can be exploited for their clearance. In this conference, we aim to bring together scientists studying DNA replication and repair, with those interested in how DNA damage can influence cancer and ageing.

Key Sessions

  • Pathways for repair of damaged replication forks
  • Systems for site-specific perturbation of replication
  • Chromosome fragility caused by difficult-to-replicate loci – sources and roles of DNA repair proteins
  • Replication perturbation as a driver of tumorigenesis and ageing
  • Exploitation of replication defects in cancer treatment
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Jun
27
2:00pm 2:00pm

London Cell Cycle Club

Our aims:
* Encourage plenty of discussions in a relaxed atmosphere.
* Inspire new collaborations and investigations.
* Provide a unique opportunity for students and post-docs to participate and present new and excited unpublished data.
 
What we provide:
* Four talks on exciting new research in the cell cycle field
* A one-hour seminar from a leader in the field; Steve West
* Coffee and tea break to socialize between talks
* Drinks and snacks to network after the meeting

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Jun
26
to Jun 28

Deubiquitinases - from structure to physiology

Recent years have seen great progress in assigning specific DUBs to biological pathways and in understanding the structural underpinning of their activity, specificity and regulation. Moreover, DUBs are emerging as a novel class of druggable targets in cancer, neurodegeneration, infection and inflammation. This conference will provide the first international meeting dedicated to this class of enzymes, encompassing structural, physiological and translational aspects. It will bring together international leaders in the field together with early stage researchers, in a setting and atmosphere aimed at fostering collegiality and collaboration. In addition to invited speakers, a number of talks will be selected from the submitted abstracts.

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Jun
17
to Jun 19

15th International Wolfsberg Meeting on Molecular Radiation Biology/Oncology 2017

The meeting will cover basic mechanisms and clinical perspectives of the three most relevant cutting-edge topics of molecular radiation biology/oncology:
Topic I “DNA Repair and Signaling”
Topic II “Influence of Microenvironmental Parameters on Radiation Response of Tumor and Normal Tissue”
Topic III “Biomarkers and Interventional Strategies in Radiation Oncology”

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May
17
to May 19

PARP2017

The aim of this meeting is to establish a new forum for the PARP community in the form of a bi-annual reunion in an intercalating fashion to the CSHL meetings that are held every even year. The topics will cover all PARP-related fields from basic science (molecular and physiological studies) to drug development and applied clinical research. We would also like to commit ourselves towards offering a well-selected program to facilitate the training of young researchers and providing a forum to present their work.

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May
15
to May 20

Aging and Mechanisms of Aging-Related Disease

Populations are aging rapidly worldwide, particularly in Asia, driving a strong interest in aging/longevity research. This Keystone Symposia meeting will capture the cutting-edge front of this exciting field of science, covering essential aspects of aging/longevity research, including critical signaling pathways and regulators, inter-tissue communication, stem cells, stress and damage responses, cellular senescence, physiological rhythms, human genetics and mental well-being (happiness). Because aging is a systemic phenomenon, it is important to address various layers of the aging/longevity-controlling hierarchy, particularly focusing on metabolic regulation, including mitochondria, NAD+, oxidative stress, inflammation, protein homeostasis, autophagy and many other age-associated pathophysiologies. The outcome of these studies needs to be translated to resolve social and economic issues caused by rapidly aging societies. Novel therapeutic and preventive interventions have been explored and developed as a growing attempt to meet the unmet needs of our aging societies, and these new aspects of aging/longevity research and the gaps in knowledge between the basic science and practical applications will also be covered in the meeting. There is a growing body of evidence that our modern lifestyle, such as the heavy use of blue light in smart phones and tablet computers, affects physiological rhythms and metabolism, promoting age-associated diseases such as obesity, diabetes, cancer and depression. Therefore, it is now time to think differently about what we can do to deal with all these problems in light of recent progress in this exciting field of science.

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May
7
to May 11

FEBS Workshop: Nucleotide excision repair and crosslink repair - from molecules to mankind

This workshop, will bring together up to a maximum of one hundred scientists to discuss our current understanding of how protein machines assemble and sort through genomic DNA for specific damaged sites which are repaired through nucleotide excision repair or inter-strand crosslink repair. Many endogenous agents, environmental toxins and chemotherapeutic agents cause DNA damage that is repaired through these two pathways. DNA damage recognition and repair is a dynamic process that spans time scales over several orders of magnitudes and the study of which uses a wide range of tools, including: molecular dynamics, NMR spectroscopy, X-ray crystallography, light and atomic force microscopy through to genetics, classic biochemistry and confocal in vivo imaging techniques. The workshop will move from molecules to man and include a discussion of several syndromes associated with premature aging and cancer and caused by poor repair of these damaged substrates.

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Apr
20
4:15pm 4:15pm

Genome rearrangements and mutation signatures in development and cancer

This meeting will bring together leading researchers in genomics and classical mechanistic biology, in an effort to decode the information contained in mutation signatures, genome rearrangements, and alterations of karyotype in human disease. The program will highlight the latest developments in this exciting field.

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Apr
18
to Apr 22

The Ubiquitin Family

The meeting will cover current work on the structure, regulation and function of ubiquitin and ubiquitin-like proteins in biology. The meeting is intended to provide a format for the exchange of ideas and information, to discuss the latest research findings and technical advances, and to facilitate interaction amongst groups active in diverse systems.

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Apr
10
to Apr 12

Genes and Cancer Annual Meeting

Topics under discussion will include ‘Novel aspects of programmed cell death’, ‘Immune cells and Inflammation’, ‘Model Organisms in Cancer Research’ and ‘Novel Targets and Strategies for Therapy’. In addition, and in line with our commitment to promote early career scientists, the programme will also feature 10 short talks, selected from submitted abstracts.

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Apr
5
to Apr 7

Genomics of rare diseases

This year’s theme is ‘Discovery and Care’; we aim to explore how cutting-edge genomic research translates into clinical care and informs our understanding of the biology of rare disease.

The conference features the latest findings related to the genomic basis of rare diseases, providing powerful insights into human biology, disease mechanisms and therapeutic approaches. As genomic sequencing becomes more available in the hospital setting we also examine the opportunities and challenges for clinical practice.

This year’s meeting will focus on the emerging role of non-coding variants in disease, how mosaicism and imprinting impact health and disease, and the emerging technologies used to understand the mechanisms of rare disease. We will also include a session on rare disease clinical trials and will debate current ethical issues in genomic medicine.

This conference provides an excellent multi-disciplinary forum for clinicians (consultants and trainees), research scientists, bioinformaticians and technology developers interested in understanding the impact of recent advances in genomics and technology on the care of patients with rare diseases.

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Apr
2
to Apr 6

Genomic Instability and DNA Repair

  • Santa Fe Community Convention Centre, (map)
  • Google Calendar ICS

Joint with the meeting on DNA Replication and Recombination

Genome stability is the foundation upon which all cellular and organismal processes depend. This conference will grapple with the intricate array of biochemical reactions orchestrated by the cell to replicate, repair and segregate chromosomes accurately despite constant threats from spontaneous and environmentally-induced damage.

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Mar
29
to Mar 30

Cells as models of disease and new therapeutics

Session Topics

  • Immuno-oncology
  • Single cell analysis including transcriptomics, NGS, micro-fluidics
  • Immunotherapy
  • Physiologically relevant 3D models & scale-up

The meeting will bring together world class speakers and leading academic and industry experts who will discuss the challenges and opportunities for cells as models of disease to improve the success of drug discovery and to develop new therapeutic agents. Hear up-to-date views on this exciting and rapidly evolving area, including presentations on the latest advances and technology breakthroughs.

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Mar
27
to Mar 28

The Ageing Cell Conference

  • Babraham Research Campus (map)
  • Google Calendar ICS

The conference will bring together an international community of researchers with an interest in immunology, epigenetics, genetics, signalling and ageing to discuss current understanding and recent advances in ageing research at the cellular level. Join us for talks from Professor David Gems and Professor Dame Linda Partridge (Institute of Healthy Ageing, UCL), and Professor David Sabatini (Whitehead Institute, MIT).

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Mar
20
to Mar 24

International Ataxia Telangiectasia Conference (ATW2017)

  • The FIRC Institute of Molecular Oncology Foundation (map)
  • Google Calendar ICS

The International Ataxia-Telangiectasia Workshops (ATW) is a unique conference that focuses on the various aspects of ATM biology, going from the basic mechanisms underlying the function of ATM and its related proteins to the more clinical aspects of Ataxia-Telangiectasia.

With the coming of age of new analytical methods made available by precision medicine, including sophisticated genomic, metabolomics and proteomic analysis and new powerful tools such as CRISPR/CAS9 we are getting closer to more defined understanding of the complex cellular pathways regulated by ATM, which is emerging as key player in human physiopathology in children, adults and aging population.

ATW2017 will bring together scientists interested in many aspects of ATM biology with the intent of building a comprehensive understanding of this complex pathway and to propose new avenues to treat the devastating diseases caused by ATM malfunction such as cancer and Ataxia-Telangiectasia.

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Mar
17
to Mar 18

ESMO Symposium on Signalling Pathways in Cancer. Focusing on DNA Damage Response

The objective of the ESMO Symposium on Signalling Pathways in Cancer is to bring together basic scientists, academics, clinical researchers and industry researchers, medical and young oncologists with a special interest in the field in order to facilitate knowledge sharing through a series of interactive sessions and workshops.

The focus of the Symposium is on the preclinical and clinical issues relevant for targeting DNA damage response and the effect of systemic and radiation therapies.

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Mar
5
to Mar 8

Keystone conference "Rare and undiagnosed diseases: Discovery and models of precision therapy"

Of the 7000 known rare diseases, only a fraction have their molecular and mechanistic bases delineated, and many other diseases have yet to be discovered. Characterization of these disorders will reveal new biochemical pathways and cell biological processes, point to potential drug targets, and provide hope for millions of affected individuals. This meeting will address approaches and best practices in pursuing rare and undiagnosed disorders, limitations in data sharing as a barrier to new disease discovery, and examples of successful descriptions of new diseases, mechanisms, and treatments. Specific aims include fostering the development of expertise in rare diseases and the definition of their natural histories; an international network of scientists and physicians collaborating on new disease discovery by sharing phenotypic and sequence data; and new therapeutic approaches based upon rare and new disease mechanisms. Through this meeting, participants should become familiar with rare and undiagnosed disease programs, acquire insights into new disease mechanisms, learn about potential therapeutic targets, and establish collaborations that enhance rare disorder expertise and new disease discovery. The meeting will bring together physicians who are expert in rare disorders with scientists who know metabolic pathways and mechanisms, advancing understanding and therapy. A desired outcome of the meeting includes developing lists of clinical and basic research experts for synergistic collaborations, and creating an international organization to perpetuate the joint investigation of rare and new diseases.

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