Synopsis

Despite tremendous advances made by the field, a significant number of cancer patients still fail to receive benefit from state-of-the art cancer immunotherapies. Overcoming this clinical gap will require fresh perspectives focused not only on the effector T cell but the network of interactions between adaptive, innate, stromal, and tumor cells that evolve over time and across anatomical sites to govern disease progression and response to therapy.  This conference will provide a platform to explore the interplay between developing tumors and the resident and circulating immune landscape, examining how interactions within the tumor micro- and macro- environments shape systemic immune surveillance. Emphasis will be placed on a holistic, systems-level approach to dissecting, perturbing, and treating the cancer ecosystem with spatial and temporal resolution.