Chromosomal instability and chromosomal alterations are key drivers of tumour initiation, evolution, heterogeneity, and response to therapy. From aneuploidy and translocations to chromothripsis and ecDNA formation, cancer cells frequently experience catastrophic genomic events that reshape their genome and massively change their phenotype.

The EACR Conference on Chromosomes in Crisis: From Chromosomal Instability to Catastrophes in Cancer Genomes will bring together leading experts to explore the mechanisms, consequences, and therapeutic vulnerabilities associated with these genomic rearrangements. Join us in Berlin, Germany, to uncover how chromosomal chaos shapes cancer biology and opens new avenues for clinical intervention.