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Posts in 2016
Specific Roles of XRCC4 Paralogs PAXX and XLF during V(D)J Recombination

A new paper, published in Cell Reports, demonstrates that PAXX and XLF (paralogs of the nonhomologous endjoining factor XRCC4) have distinct roles during V(D)J recombination. V(D)J recombination is the process by which T cells and B cells randomly assemble different gene segments – known as variable (V), diversity (D) and joining (J) genes – in order to generate unique receptors (known as antigen receptors) that can collectively recognize many different types of molecule. PAXX and XLF are required to join broken DNA ends generated during antigen receptor gene assembly. This work was the result of a collaboration between our lab and that of Ludovic Deriano at the Pasteur Institute.

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2016Michael Lakeland