This conference will focus on cutting-edge trans-disciplinary methodologies, new basic and clinical findings, plus structural and mechanistic insights for dynamic complexes acting in DNA repair, replication, inflammation and their intersections. The talks and discussions will emphasize foundational knowledge that is pivotal for pioneering research on DNA damage responses, for reverse translation from clinical findings to molecular understanding, and for forward translation from mechanisms to advanced biomarkers, clinical trials and therapies. Informative talks and poster sessions with vibrant discussions will foster productive interactions, collaborations, and insights that are not to be missed.