This meeting will focus on the discussion of the role of chromatin architecture, epigenetics, stem and single cell biology in cancer and other diseases. The talks will cover a broad range of topics, including chromosome organisation, long-range interactions, chromatin assembly, stem cell regulation/differentiation, RNA-based mechanisms, transcription regulation, DNA methylation and hydroxymethylation, exploiting the power of genome engineering technologies, single-cell approaches, cutting edge epigenomics and imaging approaches and novel cell systems such as organoids.