In this conference, we aim to bring together researchers working on understanding DNA damage responses in the context of complex and dynamic cellular environments. This is an exciting and fast moving area, and this conference features an excellent international line-up of speakers. The programme will address the challenges of understanding this complex field and will emphasise new experimental approaches for interrogating these pathways. We will also consider how recent advances can be exploited in the clinic.

Why is this conference important?

Knowing how cells respond to DNA damage is critical to our understanding of tumourigenesis, genomic instability, and the cellular response to DNA-damaging chemotherapy and radiotherapy. DNA damage responses take place in the context of chromatin and in the midst of ongoing transcription and replication. Moreover, the metabolic environment, which is altered in tumour cells, influences these activities.

Target audience

This conference will be relevant to participants from different fields of cancer research, including radiation biology, DNA damage responses, DNA repair, epigenetics, and cancer biology. We have created a programme that brings together basic scientists with translational and clinical researchers.  Given its translational character, the conference is also of interest for pharma companies. During the meeting, there will be great opportunities for young scientists to present their work and meet the experts in the field, and we aim to create an open and engaging environment for networking and discussion.

Topics to be covered

• DNA damage responses

• Epigenetic and metabolic impacts on DNA repair

• Interplay between transcription and DNA repair

• Immune responses in the context of DNA damage

• Implications for radiotherapy