Protein signaling is the cells most important regulatory mechanism to appropriately respond to internal and external cues. This is afforded by a wealth of posttranslational modifications, which expands the functional diversity of the human proteome by several orders of magnitude. Most therapeutic drugs are directed against proteins, or are proteins themselves, and protein-related technologies promise to revolutionize our understanding of the complex wiring of biological systems. This meeting will bring together world-leading researchers in the area of protein signaling with a focus on protein-driven mechanisms that are relevant to physiology and disease. The meeting will also have a strong emphasis on the emerging single cell and single-molecule technologies as well as on the advances in proteomics, network biology and structural biology. Finally, an important focus will be bridging fundamental discoveries to clinical relevant applications.